ANKRD32 [The Human Chemical-Genetic Interaction Map Project]

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======= ANKRD32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLF1
  * **<color #00a2e8>Official Name</color>**: SMC5-SMC6 complex localization factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84250|84250]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQI6|Q9BQI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKRD32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKRD32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). {ECO:0000269|PubMed:25931565}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to site of double-strand break|
|positive regulation of maintenance of mitotic sister chromatid cohesion|
|positive regulation of maintenance of sister chromatid cohesion|
|regulation of maintenance of sister chromatid cohesion|
|regulation of maintenance of mitotic sister chromatid cohesion|
|positive regulation of sister chromatid cohesion|
|nuclear inclusion body|
|positive regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid cohesion|
|positive regulation of chromosome segregation|
|positive regulation of double-strand break repair|
|positive regulation of mitotic nuclear division|
|site of double-strand break|
|protein localization to chromosome|
|positive regulation of nuclear division|
|positive regulation of DNA repair|
|nucleosome|
|regulation of mitotic sister chromatid segregation|
|regulation of double-strand break repair|
|regulation of sister chromatid segregation|
|positive regulation of response to DNA damage stimulus|
|regulation of chromosome segregation|
|regulation of DNA repair|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|regulation of response to DNA damage stimulus|
|positive regulation of protein complex assembly|
|protein-containing complex binding|
|positive regulation of cell cycle process|
|ubiquitin protein ligase binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|regulation of protein complex assembly|
|centrosome|
|DNA repair|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cellular response to stress|
|protein localization to organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of cellular component biogenesis|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|regulation of response to stress|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-3.11|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.63|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.48|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.41|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.08|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.07|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.03|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.95|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.91|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.76|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.75|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.73|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.73|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.72|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.93|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.29|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18893
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKRD32 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>