ANKRD32

Gene Information

Official Symbol: SLF1
Official Name: SMC5-SMC6 complex localization factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 84250
UniProt: Q9BQI6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). {ECO:0000269|PubMed:25931565}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aphidicolin 0.4μM R08 exp440	-3.11
Pterostilbene 16μM R02 exp78	-2.63
Campthothecin 0.001μM R06 exp270	-2.48
Bortezomib 0.005μM R00 exp6	-2.41
Rucaparib 6.5μM R08 exp520	-2.08
Disulfiram 4.3μM R06 exp281	-2.07
Olaparib 4μM R08 exp512	-2.03
ML-792 0.2μM R08 exp505	-1.95
Latrunculin-B 10μM R07 exp374	-1.91
Cryptotanshinone 12μM R05 exp227	-1.76
Mubritinib 0.2μM R01 exp48	-1.75
Hydroxyurea 100μM R07 exp329	-1.73
Lead acetate 990μM R08 exp496	-1.73
Caffeine 2600μM R08 exp463	-1.72
Golgicide-A 2μM R03 exp121	1.93
Diepoxybutane 3μM R07 exp354	2.29
Nutlin-3A 1.6μM R06 exp294	2.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18893
Expression level (log2 read counts): 5.31

Expression Distribution

protein localization to site of double-strand break
positive regulation of maintenance of mitotic sister chromatid cohesion
positive regulation of maintenance of sister chromatid cohesion
regulation of maintenance of sister chromatid cohesion
regulation of maintenance of mitotic sister chromatid cohesion
positive regulation of sister chromatid cohesion
nuclear inclusion body
positive regulation of mitotic sister chromatid segregation
regulation of sister chromatid cohesion
positive regulation of chromosome segregation
positive regulation of double-strand break repair
positive regulation of mitotic nuclear division
site of double-strand break
protein localization to chromosome
positive regulation of nuclear division
positive regulation of DNA repair
nucleosome
regulation of mitotic sister chromatid segregation
regulation of double-strand break repair
regulation of sister chromatid segregation
positive regulation of response to DNA damage stimulus
regulation of chromosome segregation
regulation of DNA repair
positive regulation of mitotic cell cycle
regulation of mitotic nuclear division
positive regulation of chromosome organization
regulation of nuclear division
positive regulation of DNA metabolic process
regulation of response to DNA damage stimulus
positive regulation of protein complex assembly
protein-containing complex binding
positive regulation of cell cycle process
ubiquitin protein ligase binding
regulation of chromosome organization
regulation of DNA metabolic process
positive regulation of cell cycle
regulation of protein complex assembly
centrosome
DNA repair
positive regulation of cellular component biogenesis