ANKRD6

Gene Information

Official Symbol: ANKRD6
Official Name: ankyrin repeat domain 6
Aliases and Previous Symbols: N/A
Entrez ID: 22881
UniProt: Q9Y2G4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8385
Expression level (log2 read counts): 2.02

Expression Distribution

Ank
Ank 2

positive regulation of Wnt signaling pathway, planar cell polarity pathway
positive regulation of non-canonical Wnt signaling pathway
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of non-canonical Wnt signaling pathway
regulation of establishment of planar polarity
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
regulation of morphogenesis of an epithelium
regulation of JNK cascade
negative regulation of Wnt signaling pathway
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of animal organ morphogenesis
regulation of canonical Wnt signaling pathway
regulation of Wnt signaling pathway
positive regulation of MAPK cascade
intracellular membrane-bounded organelle
regulation of cellular response to stress
regulation of MAPK cascade
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
regulation of anatomical structure morphogenesis
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of response to stress
regulation of phosphorylation
positive regulation of cellular protein metabolic process
negative regulation of response to stimulus
positive regulation of signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process