ANO5 [The Human Chemical-Genetic Interaction Map Project]

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======= ANO5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANO5
  * **<color #00a2e8>Official Name</color>**: anoctamin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=203859|203859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q75V66|Q75V66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANO5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANO5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608662|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:23047743}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Anoctamin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular calcium activated chloride channel activity|
|chloride transport|
|vesicle|
|protein dimerization activity|
|inorganic anion transport|
|anion transport|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.87|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.72|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.7|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.7|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.78|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.85|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.88|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.07|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.1|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.37|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.48|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18707
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANO5 Expression in NALM6 Cells: -2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>