ANO5

Entrez Summary: This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009].
UniProt Summary: Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:23047743}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lenalidomide 20μM R07 exp375	-1.87
Nifuroxazide 5μM R03 exp102	-1.72
JQ1 0.01μM R03 exp130	-1.7
Phenformin 20μM R05 exp212	1.7
Tanespimycin 14μM R08 exp527	1.78
SNS-032 15μM R08 exp443	1.85
Rotenone 0.07μM R08 exp431	1.88
Taxol 0.004μM R03 exp103	2.07
ABT-702 0.1μM R06 exp260	2.1
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.37
QNZ 0.01μM R05 exp241	2.48
Calcipotriol 5μM R08 exp464	2.76

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intracellular calcium activated chloride channel activity
chloride transport
vesicle
protein dimerization activity
inorganic anion transport
anion transport
endoplasmic reticulum membrane
ion transmembrane transport
transmembrane transport
ion transport