ANO9

Gene Information

Official Symbol: ANO9
Official Name: anoctamin 9
Aliases and Previous Symbols: N/A
Entrez ID: 338440
UniProt: A1A5B4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016].
UniProt Summary: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000250|UniProtKB:P86044, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6750
Expression level (log2 read counts): -1.79

Expression Distribution

negative regulation of intracellular calcium activated chloride channel activity
negative regulation of inorganic anion transmembrane transport
negative regulation of chloride transport
regulation of intracellular calcium activated chloride channel activity
calcium activated phosphatidylserine scrambling
negative regulation of anion channel activity
calcium activated phospholipid scrambling
calcium activated phosphatidylcholine scrambling
calcium activated galactosylceramide scrambling
regulation of inorganic anion transmembrane transport
regulation of chloride transport
regulation of anion channel activity
phospholipid scramblase activity
negative regulation of anion transmembrane transport
intracellular calcium activated chloride channel activity
plasma membrane phospholipid scrambling
regulation of anion transmembrane transport
negative regulation of anion transport
phospholipid translocation
lipid translocation
regulation of membrane lipid distribution
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
phospholipid transport
plasma membrane organization
regulation of anion transport
negative regulation of ion transmembrane transport
chloride transport
negative regulation of transmembrane transport
organophosphate ester transport
negative regulation of ion transport
inorganic anion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
lipid transport
lipid localization
endomembrane system organization
organic anion transport
regulation of ion transmembrane transport