ANP32E [The Human Chemical-Genetic Interaction Map Project]

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======= ANP32E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANP32E
  * **<color #00a2e8>Official Name</color>**: acidic nuclear phosphoprotein 32 family member E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81611|81611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTT0|Q9BTT0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANP32E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANP32E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609611|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatase inhibitor activity|
|Swr1 complex|
|histone exchange|
|ATP-dependent chromatin remodeling|
|histone binding|
|nucleosome organization|
|chromatin remodeling|
|protein-DNA complex subunit organization|
|cytoplasmic vesicle|
|chromatin organization|
|negative regulation of catalytic activity|
|chromosome organization|
|negative regulation of molecular function|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.7|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.71|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.79|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.9|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.02|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.08|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.12|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.41|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANP32E Expression in NALM6 Cells: 7.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>