ANP32E

Entrez Summary: N/A
UniProt Summary: Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-LSD1 10μM R03 exp123	1.7
Docosahexaenoic-acid 50μM R07 exp356	1.71
LB-100 2μM R05 exp210	1.79
Rapamycin 10μM R00 exp30	1.9
CCCP 1μM R00 exp11	2.02
Cycloheximide 0.02μM R00 exp14	2.08
Wortmannin 0.5μM R00 exp37	2.12
MK-1775 0.32μM R02 exp75	2.41
Rapamycin 1μM R00 exp29	3.02

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatase inhibitor activity
Swr1 complex
histone exchange
ATP-dependent chromatin remodeling
histone binding
nucleosome organization
chromatin remodeling
protein-DNA complex subunit organization
cytoplasmic vesicle
chromatin organization
negative regulation of catalytic activity
chromosome organization
negative regulation of molecular function
protein-containing complex subunit organization