ANPEP

Entrez Summary: N/A
UniProt Summary: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. {ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

metalloaminopeptidase activity
aminopeptidase activity
peptide catabolic process
peptide binding
metallopeptidase activity
endoplasmic reticulum-Golgi intermediate compartment
virus receptor activity
viral entry into host cell
secretory granule membrane
entry into host cell
entry into host
interaction with host
viral life cycle
signaling receptor activity
lysosomal membrane
angiogenesis
external side of plasma membrane
blood vessel morphogenesis
neutrophil degranulation
blood vessel development
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
vasculature development
cardiovascular system development
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
peptide metabolic process
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
tube morphogenesis
viral process
regulated exocytosis
leukocyte mediated immunity
symbiotic process
cellular amide metabolic process
exocytosis