ANXA2 [The Human Chemical-Genetic Interaction Map Project]

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======= ANXA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANXA2
  * **<color #00a2e8>Official Name</color>**: annexin A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=302|302]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07355|P07355]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANXA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANXA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). {ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Annexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PCSK9-AnxA2 complex|
|metabolism of substance in other organism involved in symbiotic interaction|
|positive regulation of low-density lipoprotein receptor activity|
|catabolism by organism of macromolecule in other organism involved in symbiotic interaction|
|positive regulation of low-density lipoprotein particle receptor binding|
|metabolism by host of substance in symbiont|
|multi-organism metabolic process|
|metabolism by host of symbiont macromolecule|
|multi-organism catabolic process|
|catabolism by host of symbiont protein|
|metabolism by organism of protein in other organism involved in symbiotic interaction|
|bone sialoprotein binding|
|catabolism by organism of protein in other organism involved in symbiotic interaction|
|modulation of development of symbiont involved in interaction with host|
|catabolism by host of substance in symbiont|
|voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels|
|catabolism by host of symbiont macromolecule|
|negative regulation of development of symbiont involved in interaction with host|
|metabolism of macromolecule in other organism involved in symbiotic interaction|
|catabolism of substance in other organism involved in symbiotic interaction|
|metabolism by host of symbiont protein|
|positive regulation of receptor-mediated endocytosis involved in cholesterol transport|
|negative regulation of low-density lipoprotein particle receptor catabolic process|
|positive regulation of low-density lipoprotein particle clearance|
|regulation of low-density lipoprotein particle receptor binding|
|molecular function regulator|
|negative regulation of receptor catabolic process|
|regulation of receptor-mediated endocytosis involved in cholesterol transport|
|positive regulation of intracellular lipid transport|
|positive regulation of intracellular cholesterol transport|
|phospholipase A2 inhibitor activity|
|positive regulation of intracellular sterol transport|
|regulation of low-density lipoprotein particle receptor catabolic process|
|positive regulation of lipoprotein particle clearance|
|myelin sheath adaxonal region|
|negative regulation by host of symbiont molecular function|
|modulation by host of symbiont molecular function|
|endocardial cell differentiation|
|macropinosome|
|osteoclast development|
|cardiac endothelial cell differentiation|
|negative regulation of molecular function in other organism|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|regulation of intracellular lipid transport|
|regulation of intracellular cholesterol transport|
|regulation of intracellular sterol transport|
|modulation of molecular function in other organism|
|regulation of receptor catabolic process|
|modulation of molecular function in other organism involved in symbiotic interaction|
|positive regulation of receptor binding|
|positive regulation of vesicle fusion|
|virion binding|
|Schmidt-Lanterman incisure|
|membrane raft assembly|
|regulation of low-density lipoprotein particle clearance|
|endocardium development|
|positive regulation of vacuole organization|
|regulation of plasminogen activation|
|S100 protein binding|
|positive regulation of receptor recycling|
|positive regulation by host of viral process|
|regulation of lipoprotein particle clearance|
|cadherin binding involved in cell-cell adhesion|
|positive regulation of chondrocyte differentiation|
|membrane raft organization|
|fibrinolysis|
|positive regulation of sterol transport|
|positive regulation of cholesterol transport|
|regulation of receptor recycling|
|regulation of receptor binding|
|bone cell development|
|response to thyroid hormone|
|modulation by host of viral process|
|extrinsic component of plasma membrane|
|regulation of vesicle fusion|
|protein heterotetramerization|
|positive regulation of cartilage development|
|growth plate cartilage development|
|membrane assembly|
|membrane biogenesis|
|endochondral bone growth|
|regulation of vacuole organization|
|osteoclast differentiation|
|regulation of cholesterol transport|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|interleukin-12-mediated signaling pathway|
|regulation of sterol transport|
|collagen fibril organization|
|cellular response to interleukin-12|
|response to interleukin-12|
|positive regulation of fibroblast proliferation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|regulation of chondrocyte differentiation|
|negative regulation of coagulation|
|positive regulation of receptor-mediated endocytosis|
|calcium channel activity|
|calcium-dependent phospholipid binding|
|myeloid cell development|
|phosphatidylserine binding|
|calcium-dependent protein binding|
|positive regulation of lipid transport|
|positive regulation of viral life cycle|
|regulation of protein processing|
|regulation of protein maturation|
|regulation of cartilage development|
|modification by host of symbiont morphology or physiology|
|negative regulation of wound healing|
|endochondral bone morphogenesis|
|body fluid secretion|
|cytoskeletal protein binding|
|phosphatidylinositol-4,5-bisphosphate binding|
|interaction with symbiont|
|regulation of blood coagulation|
|regulation of hemostasis|
|positive regulation of lipid localization|
|regulation of fibroblast proliferation|
|lipid droplet|
|regulation of coagulation|
|endothelial cell differentiation|
|negative regulation of response to wounding|
|negative regulation of cellular protein catabolic process|
|basement membrane|
|azurophil granule lumen|
|ruffle|
|biomineralization|
|biomineral tissue development|
|positive regulation of protein binding|
|endothelium development|
|vesicle budding from membrane|
|organ growth|
|sarcolemma|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|melanosome|
|protease binding|
|cell-cell adherens junction|
|protein heterooligomerization|
|regulation of lipid transport|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|myeloid leukocyte differentiation|
|bone morphogenesis|
|cardiocyte differentiation|
|late endosome membrane|
|positive regulation of calcium ion transport|
|negative regulation of protein catabolic process|
|cell cortex|
|regulation of lipid localization|
|regulation of wound healing|
|vesicle|
|regulation of viral life cycle|
|Rab GTPase binding|
|protein tetramerization|
|modification of morphology or physiology of other organism|
|midbody|
|regulation of response to wounding|
|cartilage development|
|positive regulation of binding|
|protein localization to plasma membrane|
|basolateral plasma membrane|
|calcium ion transmembrane transport|
|bone development|
|regulation of endocytosis|
|regulation of viral process|
|positive regulation of intracellular transport|
|negative regulation of multi-organism process|
|regulation of protein binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|myeloid cell differentiation|
|connective tissue development|
|membrane raft|
|protein localization to cell periphery|
|skeletal system morphogenesis|
|regulation of calcium ion transport|
|regulation of cellular protein catabolic process|
|calcium ion transport|
|negative regulation of cellular catabolic process|
|early endosome|
|endosome|
|positive regulation of ion transport|
|divalent metal ion transport|
|vesicle organization|
|lysosomal membrane|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|angiogenesis|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|extracellular matrix organization|
|regulation of intracellular transport|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|regulation of binding|
|regulation of protein catabolic process|
|extracellular structure organization|
|regulation of metal ion transport|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|protein localization to membrane|
|blood vessel development|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|skeletal system development|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|vasculature development|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|heart development|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|cell surface|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|protein catabolic process|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of proteolysis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|negative regulation of catalytic activity|
|exocytosis|
|interspecies interaction between organisms|
|cation transport|
|regulation of cellular catabolic process|
|tube development|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|ion transmembrane transport|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|regulation of catabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|transmembrane transport|
|regulation of organelle organization|
|positive regulation of developmental process|
|ion transport|
|RNA binding|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.88|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.82|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.78|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16709
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANXA2 Expression in NALM6 Cells: 3.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>