ANXA2
Gene Information
- Official Symbol: ANXA2
- Official Name: annexin A2
- Aliases and Previous Symbols: N/A
- Entrez ID: 302
- UniProt: P07355
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). {ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.
Pfam Domains GO Terms
Pfam Domains
| Annexin |
GO Terms
| PCSK9-AnxA2 complex |
| metabolism of substance in other organism involved in symbiotic interaction |
| positive regulation of low-density lipoprotein receptor activity |
| catabolism by organism of macromolecule in other organism involved in symbiotic interaction |
| positive regulation of low-density lipoprotein particle receptor binding |
| metabolism by host of substance in symbiont |
| multi-organism metabolic process |
| metabolism by host of symbiont macromolecule |
| multi-organism catabolic process |
| catabolism by host of symbiont protein |
| metabolism by organism of protein in other organism involved in symbiotic interaction |
| bone sialoprotein binding |
| catabolism by organism of protein in other organism involved in symbiotic interaction |
| modulation of development of symbiont involved in interaction with host |
| catabolism by host of substance in symbiont |
| voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels |
| catabolism by host of symbiont macromolecule |
| negative regulation of development of symbiont involved in interaction with host |
| metabolism of macromolecule in other organism involved in symbiotic interaction |
| catabolism of substance in other organism involved in symbiotic interaction |
| metabolism by host of symbiont protein |
| positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| negative regulation of low-density lipoprotein particle receptor catabolic process |
| positive regulation of low-density lipoprotein particle clearance |
| regulation of low-density lipoprotein particle receptor binding |
| molecular function regulator |
| negative regulation of receptor catabolic process |
| regulation of receptor-mediated endocytosis involved in cholesterol transport |
| positive regulation of intracellular lipid transport |
| positive regulation of intracellular cholesterol transport |
| phospholipase A2 inhibitor activity |
| positive regulation of intracellular sterol transport |
| regulation of low-density lipoprotein particle receptor catabolic process |
| positive regulation of lipoprotein particle clearance |
| myelin sheath adaxonal region |
| negative regulation by host of symbiont molecular function |
| modulation by host of symbiont molecular function |
| endocardial cell differentiation |
| macropinosome |
| osteoclast development |
| cardiac endothelial cell differentiation |
| negative regulation of molecular function in other organism |
| negative regulation of molecular function in other organism involved in symbiotic interaction |
| regulation of intracellular lipid transport |
| regulation of intracellular cholesterol transport |
| regulation of intracellular sterol transport |
| modulation of molecular function in other organism |
| regulation of receptor catabolic process |
| modulation of molecular function in other organism involved in symbiotic interaction |
| positive regulation of receptor binding |
| positive regulation of vesicle fusion |
| virion binding |
| Schmidt-Lanterman incisure |
| membrane raft assembly |
| regulation of low-density lipoprotein particle clearance |
| endocardium development |
| positive regulation of vacuole organization |
| regulation of plasminogen activation |
| S100 protein binding |
| positive regulation of receptor recycling |
| positive regulation by host of viral process |
| regulation of lipoprotein particle clearance |
| cadherin binding involved in cell-cell adhesion |
| positive regulation of chondrocyte differentiation |
| membrane raft organization |
| fibrinolysis |
| positive regulation of sterol transport |
| positive regulation of cholesterol transport |
| regulation of receptor recycling |
| regulation of receptor binding |
| bone cell development |
| response to thyroid hormone |
| modulation by host of viral process |
| extrinsic component of plasma membrane |
| regulation of vesicle fusion |
| protein heterotetramerization |
| positive regulation of cartilage development |
| growth plate cartilage development |
| membrane assembly |
| membrane biogenesis |
| endochondral bone growth |
| regulation of vacuole organization |
| osteoclast differentiation |
| regulation of cholesterol transport |
| cartilage development involved in endochondral bone morphogenesis |
| bone growth |
| interleukin-12-mediated signaling pathway |
| regulation of sterol transport |
| collagen fibril organization |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| positive regulation of fibroblast proliferation |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| regulation of chondrocyte differentiation |
| negative regulation of coagulation |
| positive regulation of receptor-mediated endocytosis |
| calcium channel activity |
| calcium-dependent phospholipid binding |
| myeloid cell development |
| phosphatidylserine binding |
| calcium-dependent protein binding |
| positive regulation of lipid transport |
| positive regulation of viral life cycle |
| regulation of protein processing |
| regulation of protein maturation |
| regulation of cartilage development |
| modification by host of symbiont morphology or physiology |
| negative regulation of wound healing |
| endochondral bone morphogenesis |
| body fluid secretion |
| cytoskeletal protein binding |
| phosphatidylinositol-4,5-bisphosphate binding |
| interaction with symbiont |
| regulation of blood coagulation |
| regulation of hemostasis |
| positive regulation of lipid localization |
| regulation of fibroblast proliferation |
| lipid droplet |
| regulation of coagulation |
| endothelial cell differentiation |
| negative regulation of response to wounding |
| negative regulation of cellular protein catabolic process |
| basement membrane |
| azurophil granule lumen |
| ruffle |
| biomineralization |
| biomineral tissue development |
| positive regulation of protein binding |
| endothelium development |
| vesicle budding from membrane |
| organ growth |
| sarcolemma |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| melanosome |
| protease binding |
| cell-cell adherens junction |
| protein heterooligomerization |
| regulation of lipid transport |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| myeloid leukocyte differentiation |
| bone morphogenesis |
| cardiocyte differentiation |
| late endosome membrane |
| positive regulation of calcium ion transport |
| negative regulation of protein catabolic process |
| cell cortex |
| regulation of lipid localization |
| regulation of wound healing |
| vesicle |
| regulation of viral life cycle |
| Rab GTPase binding |
| protein tetramerization |
| modification of morphology or physiology of other organism |
| midbody |
| regulation of response to wounding |
| cartilage development |
| positive regulation of binding |
| protein localization to plasma membrane |
| basolateral plasma membrane |
| calcium ion transmembrane transport |
| bone development |
| regulation of endocytosis |
| regulation of viral process |
| positive regulation of intracellular transport |
| negative regulation of multi-organism process |
| regulation of protein binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| myeloid cell differentiation |
| connective tissue development |
| membrane raft |
| protein localization to cell periphery |
| skeletal system morphogenesis |
| regulation of calcium ion transport |
| regulation of cellular protein catabolic process |
| calcium ion transport |
| negative regulation of cellular catabolic process |
| early endosome |
| endosome |
| positive regulation of ion transport |
| divalent metal ion transport |
| vesicle organization |
| lysosomal membrane |
| divalent inorganic cation transport |
| negative regulation of catabolic process |
| angiogenesis |
| regulation of cytosolic calcium ion concentration |
| leukocyte differentiation |
| extracellular matrix organization |
| regulation of intracellular transport |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| regulation of binding |
| regulation of protein catabolic process |
| extracellular structure organization |
| regulation of metal ion transport |
| developmental growth |
| growth |
| blood vessel morphogenesis |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| supramolecular fiber organization |
| cellular divalent inorganic cation homeostasis |
| protein localization to membrane |
| blood vessel development |
| neutrophil degranulation |
| divalent inorganic cation homeostasis |
| neutrophil activation involved in immune response |
| skeletal system development |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| cell-cell adhesion |
| positive regulation of multi-organism process |
| vasculature development |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| cardiovascular system development |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| heart development |
| regulation of vesicle-mediated transport |
| hemopoiesis |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| myeloid leukocyte activation |
| hematopoietic or lymphoid organ development |
| cation transmembrane transport |
| cell surface |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| metal ion homeostasis |
| cell activation involved in immune response |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| immune system development |
| tube morphogenesis |
| cytokine-mediated signaling pathway |
| epithelial cell differentiation |
| protein catabolic process |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| cellular chemical homeostasis |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| ion homeostasis |
| negative regulation of catalytic activity |
| exocytosis |
| interspecies interaction between organisms |
| cation transport |
| regulation of cellular catabolic process |
| tube development |
| membrane organization |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| response to hormone |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| ion transmembrane transport |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| positive regulation of transport |
| regulation of catabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| export from cell |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| identical protein binding |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| epithelium development |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| transmembrane transport |
| regulation of organelle organization |
| positive regulation of developmental process |
| ion transport |
| RNA binding |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| protein-containing complex assembly |
| cellular protein localization |
| regulation of phosphorylation |
| extracellular space |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| cell development |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rifampicin 30μM R08 exp430 | -1.88 |
| LY2090314 0.003μM R08 exp499 | -1.82 |
| NMS-873 0.07μM R07 exp380 | -1.78 |
| Asunaprenir 3μM R07 exp336 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16709
- Expression level (log2 read counts): 3.12
Expression Distribution
ANXA2 Expression in NALM6 Cells: 3.12
