ANXA3 [The Human Chemical-Genetic Interaction Map Project]

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======= ANXA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANXA3
  * **<color #00a2e8>Official Name</color>**: annexin A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=306|306]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12429|P12429]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANXA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANXA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/106490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Annexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase A2 inhibitor activity|
|specific granule|
|regulation of NMDA receptor activity|
|calcium-dependent phospholipid binding|
|calcium-dependent protein binding|
|regulation of glutamate receptor signaling pathway|
|phagocytic vesicle membrane|
|animal organ regeneration|
|regulation of neurotransmitter receptor activity|
|hippocampus development|
|positive regulation of endothelial cell migration|
|limbic system development|
|positive regulation of epithelial cell migration|
|response to glucocorticoid|
|regeneration|
|regulation of endothelial cell migration|
|response to corticosteroid|
|positive regulation of angiogenesis|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|pallium development|
|positive regulation of vasculature development|
|positive regulation of DNA metabolic process|
|regulation of epithelial cell migration|
|telencephalon development|
|regulation of ion transmembrane transporter activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|positive regulation of DNA-binding transcription factor activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of angiogenesis|
|axon|
|regulation of vasculature development|
|response to steroid hormone|
|phagocytosis|
|defense response to bacterium|
|regulation of cation transmembrane transport|
|regulation of DNA metabolic process|
|neuronal cell body|
|forebrain development|
|dendrite|
|regulation of DNA-binding transcription factor activity|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|response to bacterium|
|regulation of ion transport|
|regulated exocytosis|
|calcium ion binding|
|brain development|
|leukocyte mediated immunity|
|head development|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|secretion|
|negative regulation of molecular function|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|response to endogenous stimulus|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.75|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15775
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANXA3 Expression in NALM6 Cells: 1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>