ANXA3
Gene Information
- Official Symbol: ANXA3
- Official Name: annexin A3
- Aliases and Previous Symbols: N/A
- Entrez ID: 306
- UniProt: P12429
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
Pfam Domains GO Terms
Pfam Domains
| Annexin |
GO Terms
| phospholipase A2 inhibitor activity |
| specific granule |
| regulation of NMDA receptor activity |
| calcium-dependent phospholipid binding |
| calcium-dependent protein binding |
| regulation of glutamate receptor signaling pathway |
| phagocytic vesicle membrane |
| animal organ regeneration |
| regulation of neurotransmitter receptor activity |
| hippocampus development |
| positive regulation of endothelial cell migration |
| limbic system development |
| positive regulation of epithelial cell migration |
| response to glucocorticoid |
| regeneration |
| regulation of endothelial cell migration |
| response to corticosteroid |
| positive regulation of angiogenesis |
| homophilic cell adhesion via plasma membrane adhesion molecules |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| pallium development |
| positive regulation of vasculature development |
| positive regulation of DNA metabolic process |
| regulation of epithelial cell migration |
| telencephalon development |
| regulation of ion transmembrane transporter activity |
| cell-cell adhesion via plasma-membrane adhesion molecules |
| positive regulation of DNA-binding transcription factor activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| regulation of angiogenesis |
| axon |
| regulation of vasculature development |
| response to steroid hormone |
| phagocytosis |
| defense response to bacterium |
| regulation of cation transmembrane transport |
| regulation of DNA metabolic process |
| neuronal cell body |
| forebrain development |
| dendrite |
| regulation of DNA-binding transcription factor activity |
| regulation of ion transmembrane transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| cell-cell adhesion |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| response to growth factor |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| response to bacterium |
| regulation of ion transport |
| regulated exocytosis |
| calcium ion binding |
| brain development |
| leukocyte mediated immunity |
| head development |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of cell migration |
| response to lipid |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| export from cell |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| secretion |
| negative regulation of molecular function |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| response to endogenous stimulus |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NFN1 0.4μM R03 exp99 | 1.75 |
| LJH685 5μM R02 exp73 | 2.19 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15775
- Expression level (log2 read counts): 1.24
Expression Distribution
ANXA3 Expression in NALM6 Cells: 1.24
