AP1G1 [The Human Chemical-Genetic Interaction Map Project]

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======= AP1G1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AP1G1
  * **<color #00a2e8>Official Name</color>**: adaptor related protein complex 1 subunit gamma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=164|164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43747|O43747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AP1G1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AP1G1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adaptin N|
|Alpha adaptinC2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of natural killer cell degranulation|
|positive regulation of natural killer cell degranulation|
|AP-1 adaptor complex|
|Golgi to lysosome transport|
|endosome to pigment granule transport|
|pigment granule maturation|
|endosome to melanosome transport|
|pigment accumulation|
|cellular pigment accumulation|
|Golgi to vacuole transport|
|positive regulation of natural killer cell activation|
|GTP-dependent protein binding|
|melanosome organization|
|positive regulation of leukocyte degranulation|
|pigment granule organization|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of defense response to virus by virus|
|pigment cell differentiation|
|positive regulation of natural killer cell mediated immunity|
|regulation of natural killer cell activation|
|developmental pigmentation|
|kinesin binding|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|cellular pigmentation|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|clathrin-coated vesicle membrane|
|positive regulation of leukocyte mediated cytotoxicity|
|clathrin-coated vesicle|
|positive regulation of cell killing|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of exocytosis|
|pigmentation|
|trans-Golgi network membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|regulation of cell killing|
|post-Golgi vesicle-mediated transport|
|positive regulation of lymphocyte mediated immunity|
|lysosomal transport|
|recycling endosome|
|positive regulation of leukocyte mediated immunity|
|vacuolar transport|
|cytoplasmic vesicle membrane|
|cytosolic transport|
|Rab GTPase binding|
|regulation of lymphocyte mediated immunity|
|regulation of regulated secretory pathway|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of leukocyte mediated immunity|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of exocytosis|
|developmental maturation|
|vesicle organization|
|lysosomal membrane|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|Golgi vesicle transport|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of secretion|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|regulation of vesicle-mediated transport|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|Golgi membrane|
|regulation of cell activation|
|intracellular membrane-bounded organelle|
|viral process|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|positive regulation of immune response|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.95|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.6|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.81|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.91|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.02|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.1|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.18|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.26|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.28|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab11a|RAB11A]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AP1G1 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>