AP1G1
Gene Information
- Official Symbol: AP1G1
- Official Name: adaptor related protein complex 1 subunit gamma 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 164
- UniProt: O43747
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Pfam Domains GO Terms
Pfam Domains
| Adaptin N |
| Alpha adaptinC2 |
GO Terms
| regulation of natural killer cell degranulation |
| positive regulation of natural killer cell degranulation |
| AP-1 adaptor complex |
| Golgi to lysosome transport |
| endosome to pigment granule transport |
| pigment granule maturation |
| endosome to melanosome transport |
| pigment accumulation |
| cellular pigment accumulation |
| Golgi to vacuole transport |
| positive regulation of natural killer cell activation |
| GTP-dependent protein binding |
| melanosome organization |
| positive regulation of leukocyte degranulation |
| pigment granule organization |
| positive regulation of natural killer cell mediated cytotoxicity |
| regulation of defense response to virus by virus |
| pigment cell differentiation |
| positive regulation of natural killer cell mediated immunity |
| regulation of natural killer cell activation |
| developmental pigmentation |
| kinesin binding |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| cellular pigmentation |
| regulation of leukocyte degranulation |
| positive regulation of regulated secretory pathway |
| clathrin-coated vesicle membrane |
| positive regulation of leukocyte mediated cytotoxicity |
| clathrin-coated vesicle |
| positive regulation of cell killing |
| regulation of leukocyte mediated cytotoxicity |
| positive regulation of exocytosis |
| pigmentation |
| trans-Golgi network membrane |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| regulation of cell killing |
| post-Golgi vesicle-mediated transport |
| positive regulation of lymphocyte mediated immunity |
| lysosomal transport |
| recycling endosome |
| positive regulation of leukocyte mediated immunity |
| vacuolar transport |
| cytoplasmic vesicle membrane |
| cytosolic transport |
| Rab GTPase binding |
| regulation of lymphocyte mediated immunity |
| regulation of regulated secretory pathway |
| antigen processing and presentation of exogenous peptide antigen |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| regulation of leukocyte mediated immunity |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of exocytosis |
| developmental maturation |
| vesicle organization |
| lysosomal membrane |
| positive regulation of innate immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| Golgi vesicle transport |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| positive regulation of secretion |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| regulation of vesicle-mediated transport |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| Golgi membrane |
| regulation of cell activation |
| intracellular membrane-bounded organelle |
| viral process |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of multi-organism process |
| symbiotic process |
| regulation of secretion |
| interspecies interaction between organisms |
| positive regulation of immune response |
| Golgi apparatus |
| positive regulation of transport |
| intracellular protein transport |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of immune system process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RAB11A | 0.408 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10064
- Expression level (log2 read counts): 7.37
Expression Distribution
AP1G1 Expression in NALM6 Cells: 7.37
