AP3S1

Entrez Summary: N/A
UniProt Summary: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AP-type membrane coat adaptor complex
AP-3 adaptor complex
synaptic vesicle transport along microtubule
anterograde synaptic vesicle transport
synaptic vesicle cytoskeletal transport
synaptic vesicle transport
synaptic vesicle localization
vesicle transport along microtubule
anterograde axonal transport
vesicle cytoskeletal trafficking
axonal transport
axon cytoplasm
axo-dendritic transport
organelle transport along microtubule
insulin receptor signaling pathway
transport vesicle
cytoplasmic vesicle membrane
transport along microtubule
cellular response to insulin stimulus
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization
response to insulin
cellular response to peptide hormone stimulus
microtubule-based movement
cellular response to peptide
establishment of organelle localization
response to peptide hormone
response to peptide
transmembrane receptor protein tyrosine kinase signaling pathway
organelle localization
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
microtubule-based process
intracellular membrane-bounded organelle
enzyme linked receptor protein signaling pathway
response to hormone
Golgi apparatus