AP5M1

Entrez Summary: N/A
UniProt Summary: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death. {ECO:0000269|PubMed:18395520, ECO:0000269|PubMed:22022230}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-3.41
UM0011500 10μM R05 exp246	-2.25
MK-1775 0.32μM R02 exp75	-2.04
Cryptotanshinone 12μM R05 exp227	-1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AP-type membrane coat adaptor complex
late endosome membrane
late endosome
endosomal transport
lysosome
lysosomal membrane
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport
membrane