APBA3 [The Human Chemical-Genetic Interaction Map Project]

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======= APBA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APBA3
  * **<color #00a2e8>Official Name</color>**: amyloid beta precursor protein binding family A member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9546|9546]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96018|O96018]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APBA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APBA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604262|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enzyme inhibitor activity|
|amyloid-beta binding|
|dendritic spine|
|synapse|
|enzyme binding|
|in utero embryonic development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|perinuclear region of cytoplasm|
|negative regulation of catalytic activity|
|embryo development|
|cell-cell signaling|
|negative regulation of molecular function|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-4.69|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-4.28|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.23|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.14|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-3.14|
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.02|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.42|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.08|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.89|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.77|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.53|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.476|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.475|
|[[:human genes:t:tbc1d22b|TBC1D22B]]|0.42|
|[[:human genes:g:gpr107|GPR107]]|0.414|
|[[:human genes:a:arfgef1|ARFGEF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9960
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APBA3 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>