APBA3

Entrez Summary: N/A
UniProt Summary: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-4.69
Vemurafenib 6.6μM R02 exp89	-4.28
Clomiphene 4.4μM R02 exp68	-3.23
Monensin 0.3μM R08 exp507	-3.14
Nicotine 3000μM R08 exp510	-3.14
BH1 1μM R04 exp169	-3.02
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.42
Caffeine 2600μM R08 exp463	-2.2
PU-H71 1μM R08 exp515	-2.08
Bafilomycin-A1 0.009μM R08 exp454	-1.89
Quercetin 20μM R08 exp517	-1.77
TGF-beta1 44ng/ml R08 exp528	-1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PID
PDZ

enzyme inhibitor activity
amyloid-beta binding
dendritic spine
synapse
enzyme binding
in utero embryonic development
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
chordate embryonic development
embryo development ending in birth or egg hatching
perinuclear region of cytoplasm
negative regulation of catalytic activity
embryo development
cell-cell signaling
negative regulation of molecular function
protein transport
peptide transport
amide transport
establishment of protein localization
nitrogen compound transport