APCS
Gene Information
- Official Symbol: APCS
- Official Name: amyloid P component, serum
- Aliases and Previous Symbols: N/A
- Entrez ID: 325
- UniProt: P02743
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Pfam Domains GO Terms
Pfam Domains
| Pentaxin |
GO Terms
| modulation by host of viral catalytic activity |
| negative regulation by host of symbiont catalytic activity |
| modulation by host of viral exo-alpha-sialidase activity |
| negative regulation by host of viral glycoprotein metabolic process |
| negative regulation of exo-alpha-sialidase activity |
| negative regulation by host of viral exo-alpha-sialidase activity |
| modulation by host of viral glycoprotein metabolic process |
| modulation by host of viral molecular function |
| modulation by host of symbiont catalytic activity |
| regulation of exo-alpha-sialidase activity |
| negative regulation of catalytic activity in other organism involved in symbiotic interaction |
| modulation of catalytic activity in other organism involved in symbiotic interaction |
| negative regulation of monocyte differentiation |
| negative regulation by host of symbiont molecular function |
| modulation by host of symbiont molecular function |
| complement component C1q binding |
| negative regulation of molecular function in other organism |
| negative regulation of molecular function in other organism involved in symbiotic interaction |
| modulation of molecular function in other organism involved in symbiotic interaction |
| modulation of molecular function in other organism |
| negative regulation by host of viral process |
| virion binding |
| negative regulation of acute inflammatory response |
| negative regulation of glycoprotein metabolic process |
| low-density lipoprotein particle binding |
| chaperone-mediated protein complex assembly |
| regulation of monocyte differentiation |
| negative regulation of viral entry into host cell |
| modulation by host of viral process |
| regulation of viral entry into host cell |
| acute-phase response |
| regulation of acute inflammatory response |
| regulation of glycoprotein metabolic process |
| negative regulation of myeloid leukocyte differentiation |
| acute inflammatory response |
| modification by host of symbiont morphology or physiology |
| negative regulation of wound healing |
| interaction with symbiont |
| negative regulation of myeloid cell differentiation |
| negative regulation of viral life cycle |
| negative regulation of response to wounding |
| negative regulation of viral process |
| negative regulation of leukocyte differentiation |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| regulation of myeloid leukocyte differentiation |
| unfolded protein binding |
| negative regulation of hemopoiesis |
| negative regulation of inflammatory response |
| regulation of wound healing |
| blood microparticle |
| regulation of viral life cycle |
| modification of morphology or physiology of other organism |
| complement activation, classical pathway |
| regulation of response to wounding |
| humoral immune response mediated by circulating immunoglobulin |
| carbohydrate binding |
| complement activation |
| regulation of viral process |
| immunoglobulin mediated immune response |
| negative regulation of defense response |
| B cell mediated immunity |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of myeloid cell differentiation |
| protein folding |
| lymphocyte mediated immunity |
| regulation of leukocyte differentiation |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of inflammatory response |
| humoral immune response |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| inflammatory response |
| adaptive immune response |
| activation of immune response |
| negative regulation of cell differentiation |
| calcium ion binding |
| regulation of defense response |
| leukocyte mediated immunity |
| innate immune response |
| regulation of multi-organism process |
| symbiotic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| positive regulation of immune response |
| negative regulation of developmental process |
| defense response to other organism |
| identical protein binding |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| protein-containing complex assembly |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Alpha-Amanitin 0.5μM R00 exp5 | 1.83 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.487 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7894
- Expression level (log2 read counts): -7.68
Expression Distribution
APCS Expression in NALM6 Cells: -7.68
