APH1B

Entrez Summary: N/A
UniProt Summary: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. {ECO:0000269|PubMed:12297508}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Taxol 0.004μM R03 exp103	1.89
GSK-J4 1μM R07 exp362	2

gamma-secretase complex
Notch receptor processing, ligand-dependent
Notch receptor processing
membrane protein intracellular domain proteolysis
membrane protein proteolysis
endopeptidase activity
peptidase activity
ephrin receptor signaling pathway
transport vesicle
Notch signaling pathway
protein processing
locomotory behavior
endosome membrane
protein maturation
transmembrane receptor protein tyrosine kinase signaling pathway
behavior
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
enzyme linked receptor protein signaling pathway
endoplasmic reticulum
proteolysis
integral component of plasma membrane
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
positive regulation of molecular function
gene expression