APIP

Entrez Summary: N/A
UniProt Summary: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

methylthioribulose 1-phosphate dehydratase activity
L-methionine salvage from S-adenosylmethionine
L-methionine salvage from methylthioadenosine
S-adenosylmethionine cycle
L-methionine biosynthetic process
L-methionine salvage
amino acid salvage
pyroptosis
methionine biosynthetic process
methionine metabolic process
S-adenosylmethionine metabolic process
sulfur amino acid biosynthetic process
aspartate family amino acid biosynthetic process
cellular metabolic compound salvage
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
protein homotetramerization
protein tetramerization
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
coenzyme metabolic process
regulation of ERK1 and ERK2 cascade
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
protein homooligomerization
sulfur compound metabolic process
cofactor metabolic process
drug metabolic process
protein complex oligomerization
small molecule biosynthetic process
regulation of MAPK cascade
zinc ion binding
negative regulation of apoptotic process
negative regulation of programmed cell death
carboxylic acid metabolic process
apoptotic process