APLP1

Entrez Summary: N/A
UniProt Summary: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dexamethasone 0.006μM R07 exp351	1.88
Mdivi-1 15μM R05 exp217	2.01

alpha-2B adrenergic receptor binding
cellular response to norepinephrine stimulus
alpha-2C adrenergic receptor binding
response to norepinephrine
alpha-2A adrenergic receptor binding
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
transition metal ion binding
negative regulation of cAMP-mediated signaling
negative regulation of G protein-coupled receptor signaling pathway
regulation of cAMP-mediated signaling
basement membrane
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
regulation of G protein-coupled receptor signaling pathway
heparin binding
negative regulation of intracellular signal transduction
cellular response to organic cyclic compound
endocytosis
cellular response to organonitrogen compound
cellular response to nitrogen compound
import into cell
perinuclear region of cytoplasm
response to organic cyclic compound
apoptotic process
cell adhesion
biological adhesion
animal organ morphogenesis
response to organonitrogen compound
programmed cell death
cellular response to oxygen-containing compound
identical protein binding
response to nitrogen compound
cell death
cellular response to endogenous stimulus
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling