APOA1 [The Human Chemical-Genetic Interaction Map Project]

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======= APOA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOA1
  * **<color #00a2e8>Official Name</color>**: apolipoprotein A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=335|335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02647|P02647]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apolipoprotein|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell adhesion molecule production|
|positive regulation of phospholipid efflux|
|regulation of phospholipid efflux|
|discoidal high-density lipoprotein particle|
|high-density lipoprotein particle receptor binding|
|apolipoprotein receptor binding|
|negative regulation of very-low-density lipoprotein particle remodeling|
|apolipoprotein A-I receptor binding|
|regulation of cell adhesion molecule production|
|regulation of very-low-density lipoprotein particle remodeling|
|intermediate-density lipoprotein particle|
|peripheral nervous system axon regeneration|
|phosphatidylcholine-sterol O-acyltransferase activator activity|
|lipase inhibitor activity|
|cholesterol import|
|negative regulation of cytokine secretion involved in immune response|
|sterol import|
|regulation of intestinal cholesterol absorption|
|regulation of intestinal lipid absorption|
|regulation of Cdc42 protein signal transduction|
|spherical high-density lipoprotein particle|
|positive regulation of phospholipid transport|
|chylomicron remodeling|
|positive regulation of cholesterol esterification|
|regulation of intestinal absorption|
|regulation of phospholipid transport|
|high-density lipoprotein particle clearance|
|chylomicron assembly|
|high-density lipoprotein particle binding|
|regulation of cell-cell adhesion involved in gastrulation|
|very-low-density lipoprotein particle remodeling|
|negative regulation of heterotypic cell-cell adhesion|
|phospholipid homeostasis|
|regulation of cholesterol esterification|
|phospholipid efflux|
|chylomicron|
|protein oxidation|
|high-density lipoprotein particle assembly|
|peptidyl-methionine modification|
|triglyceride-rich lipoprotein particle remodeling|
|low-density lipoprotein particle|
|endocytic vesicle lumen|
|negative regulation of interleukin-1 beta secretion|
|reverse cholesterol transport|
|phospholipid transporter activity|
|positive regulation of cholesterol efflux|
|regulation of cytokine secretion involved in immune response|
|glucocorticoid metabolic process|
|negative regulation of lipase activity|
|cholesterol transfer activity|
|high-density lipoprotein particle remodeling|
|negative regulation of interleukin-1 secretion|
|very-low-density lipoprotein particle|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|high-density lipoprotein particle|
|cholesterol efflux|
|axon regeneration|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|endothelial cell proliferation|
|positive regulation of sterol transport|
|adrenal gland development|
|negative regulation of cytokine production involved in immune response|
|regulation of heterotypic cell-cell adhesion|
|plasma lipoprotein particle assembly|
|negative regulation of interleukin-1 beta production|
|triglyceride catabolic process|
|chemorepellent activity|
|positive regulation of steroid metabolic process|
|protein-lipid complex remodeling|
|ERK1 and ERK2 cascade|
|plasma lipoprotein particle remodeling|
|protein-containing complex remodeling|
|positive regulation of Rho protein signal transduction|
|neuron projection regeneration|
|lipid storage|
|blood vessel endothelial cell migration|
|protein-lipid complex assembly|
|negative regulation of interleukin-1 production|
|phosphatidylcholine biosynthetic process|
|acylglycerol catabolic process|
|neutral lipid catabolic process|
|triglyceride homeostasis|
|negative regulation of production of molecular mediator of immune response|
|acylglycerol homeostasis|
|regulation of gastrulation|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of digestive system process|
|vitamin transport|
|plasma lipoprotein particle clearance|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|negative chemotaxis|
|regulation of sterol transport|
|regulation of interleukin-1 beta secretion|
|protein-lipid complex subunit organization|
|sterol biosynthetic process|
|cholesterol binding|
|response to axon injury|
|positive regulation of anion transport|
|positive regulation of stress fiber assembly|
|regulation of substrate adhesion-dependent cell spreading|
|glycerolipid catabolic process|
|cholesterol transport|
|regulation of interleukin-1 secretion|
|extracellular vesicle|
|anion homeostasis|
|heat shock protein binding|
|endocytic vesicle|
|regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of lipid transport|
|positive regulation of actin filament bundle assembly|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of Ras protein signal transduction|
|endothelial cell migration|
|negative regulation of response to cytokine stimulus|
|sterol transport|
|negative regulation of cytokine secretion|
|positive regulation of phagocytosis|
|positive regulation of small GTPase mediated signal transduction|
|regulation of plasma lipoprotein particle levels|
|animal organ regeneration|
|triglyceride metabolic process|
|response to estrogen|
|phosphatidylcholine metabolic process|
|regulation of stress fiber assembly|
|cholesterol homeostasis|
|positive regulation of lipid biosynthetic process|
|sterol homeostasis|
|amyloid-beta binding|
|positive regulation of lipid localization|
|regulation of interleukin-1 beta production|
|epithelial cell migration|
|regulation of cytokine production involved in immune response|
|epithelial cell proliferation|
|epithelium migration|
|regulation of actomyosin structure organization|
|lipoprotein biosynthetic process|
|phospholipid transport|
|regulation of actin filament bundle assembly|
|integrin-mediated signaling pathway|
|tissue migration|
|regulation of interleukin-1 production|
|regulation of phagocytosis|
|regulation of anion transport|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|transforming growth factor beta receptor signaling pathway|
|retinoid metabolic process|
|phospholipid binding|
|regulation of lipid transport|
|diterpenoid metabolic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|secretory granule lumen|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|terpenoid metabolic process|
|negative regulation of immune effector process|
|endocrine system development|
|positive regulation of cell-substrate adhesion|
|organophosphate ester transport|
|steroid biosynthetic process|
|regulation of embryonic development|
|secondary alcohol metabolic process|
|platelet degranulation|
|negative regulation of protein secretion|
|lipid homeostasis|
|sterol metabolic process|
|negative regulation of inflammatory response|
|isoprenoid metabolic process|
|regulation of lipid localization|
|organic hydroxy compound transport|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|blood microparticle|
|positive regulation of lipid metabolic process|
|regulation of Rho protein signal transduction|
|negative regulation of immune response|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to transforming growth factor beta stimulus|
|regeneration|
|response to transforming growth factor beta|
|regulation of cytokine-mediated signaling pathway|
|maintenance of location|
|ameboidal-type cell migration|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|protein stabilization|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|positive regulation of supramolecular fiber organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|hormone metabolic process|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|glycerophospholipid biosynthetic process|
|negative regulation of defense response|
|regulation of cell-substrate adhesion|
|response to nutrient|
|positive regulation of cytoskeleton organization|
|glycerolipid biosynthetic process|
|negative regulation of secretion|
|receptor-mediated endocytosis|
|regulation of Ras protein signal transduction|
|phospholipid biosynthetic process|
|cytoplasmic vesicle|
|early endosome|
|steroid metabolic process|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|regulation of protein stability|
|lipid transport|
|lipid catabolic process|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|signaling receptor binding|
|regulation of inflammatory response|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|enzyme binding|
|regulation of supramolecular fiber organization|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|MAPK cascade|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|axon development|
|gland development|
|negative regulation of immune system process|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|organic anion transport|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|response to extracellular stimulus|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|cell population proliferation|
|endocytosis|
|response to wounding|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|regulation of system process|
|cell surface|
|positive regulation of organelle organization|
|neuron projection development|
|import into cell|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of secretion|
|neuron development|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|regulation of cell development|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|cell migration|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|positive regulation of transport|
|secretion by cell|
|neuron differentiation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|regulation of immune response|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15567
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOA1 Expression in NALM6 Cells: -1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>