APOA1

Gene Information

Official Symbol: APOA1
Official Name: apolipoprotein A1
Aliases and Previous Symbols: N/A
Entrez ID: 335
UniProt: P02647
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015].
UniProt Summary: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15567
Expression level (log2 read counts): -1.24

Expression Distribution

negative regulation of cell adhesion molecule production
positive regulation of phospholipid efflux
regulation of phospholipid efflux
discoidal high-density lipoprotein particle
high-density lipoprotein particle receptor binding
apolipoprotein receptor binding
negative regulation of very-low-density lipoprotein particle remodeling
apolipoprotein A-I receptor binding
regulation of cell adhesion molecule production
regulation of very-low-density lipoprotein particle remodeling
intermediate-density lipoprotein particle
peripheral nervous system axon regeneration
phosphatidylcholine-sterol O-acyltransferase activator activity
lipase inhibitor activity
cholesterol import
negative regulation of cytokine secretion involved in immune response
sterol import
regulation of intestinal cholesterol absorption
regulation of intestinal lipid absorption
regulation of Cdc42 protein signal transduction
spherical high-density lipoprotein particle
positive regulation of phospholipid transport
chylomicron remodeling
positive regulation of cholesterol esterification
regulation of intestinal absorption
regulation of phospholipid transport
high-density lipoprotein particle clearance
chylomicron assembly
high-density lipoprotein particle binding
regulation of cell-cell adhesion involved in gastrulation
very-low-density lipoprotein particle remodeling
negative regulation of heterotypic cell-cell adhesion
phospholipid homeostasis
regulation of cholesterol esterification
phospholipid efflux
chylomicron
protein oxidation
high-density lipoprotein particle assembly
peptidyl-methionine modification
triglyceride-rich lipoprotein particle remodeling