APOA4
Gene Information
- Official Symbol: APOA4
- Official Name: apolipoprotein A4
- Aliases and Previous Symbols: N/A
- Entrez ID: 337
- UniProt: P06727
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008].
- UniProt Summary: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Pfam Domains GO Terms
Pfam Domains
| Apolipoprotein |
GO Terms
| response to lipid hydroperoxide |
| negative regulation of plasma lipoprotein oxidation |
| regulation of plasma lipoprotein oxidation |
| response to stilbenoid |
| phosphatidylcholine-sterol O-acyltransferase activator activity |
| positive regulation of triglyceride catabolic process |
| regulation of intestinal lipid absorption |
| regulation of intestinal cholesterol absorption |
| chylomicron remodeling |
| regulation of intestinal absorption |
| positive regulation of cholesterol esterification |
| positive regulation of lipoprotein lipase activity |
| chylomicron assembly |
| very-low-density lipoprotein particle remodeling |
| positive regulation of triglyceride lipase activity |
| regulation of cholesterol esterification |
| regulation of triglyceride catabolic process |
| phospholipid efflux |
| chylomicron |
| removal of superoxide radicals |
| high-density lipoprotein particle assembly |
| triglyceride-rich lipoprotein particle remodeling |
| cellular response to superoxide |
| cellular response to oxygen radical |
| reverse cholesterol transport |
| response to superoxide |
| high-density lipoprotein particle remodeling |
| response to oxygen radical |
| antioxidant activity |
| cholesterol transfer activity |
| positive regulation of triglyceride metabolic process |
| innate immune response in mucosa |
| positive regulation of fatty acid biosynthetic process |
| very-low-density lipoprotein particle |
| response to hydroperoxide |
| regulation of lipoprotein lipase activity |
| high-density lipoprotein particle |
| cholesterol efflux |
| positive regulation of lipid catabolic process |
| plasma lipoprotein particle assembly |
| triglyceride catabolic process |
| hydrogen peroxide catabolic process |
| positive regulation of steroid metabolic process |
| protein-lipid complex remodeling |
| plasma lipoprotein particle remodeling |
| phosphatidylcholine binding |
| protein-containing complex remodeling |
| mucosal immune response |
| protein-lipid complex assembly |
| lipid transporter activity |
| organ or tissue specific immune response |
| positive regulation of fatty acid metabolic process |
| regulation of triglyceride metabolic process |
| acylglycerol catabolic process |
| neutral lipid catabolic process |
| triglyceride homeostasis |
| acylglycerol homeostasis |
| hydrogen peroxide metabolic process |
| superoxide metabolic process |
| regulation of digestive system process |
| cholesterol biosynthetic process |
| secondary alcohol biosynthetic process |
| plasma lipoprotein particle organization |
| regulation of cholesterol transport |
| regulation of fatty acid biosynthetic process |
| regulation of sterol transport |
| protein-lipid complex subunit organization |
| sterol biosynthetic process |
| cholesterol binding |
| leukocyte cell-cell adhesion |
| antibiotic catabolic process |
| glycerolipid catabolic process |
| regulation of lipid catabolic process |
| cholesterol transport |
| copper ion binding |
| cofactor catabolic process |
| sterol transport |
| positive regulation of lipase activity |
| regulation of plasma lipoprotein particle levels |
| triglyceride metabolic process |
| phosphatidylcholine metabolic process |
| cholesterol homeostasis |
| positive regulation of lipid biosynthetic process |
| sterol homeostasis |
| regulation of fatty acid metabolic process |
| cellular oxidant detoxification |
| phospholipid transport |
| regulation of lipase activity |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| cellular detoxification |
| antibiotic metabolic process |
| retinoid metabolic process |
| phospholipid binding |
| regulation of lipid transport |
| diterpenoid metabolic process |
| reactive oxygen species metabolic process |
| alcohol biosynthetic process |
| regulation of steroid metabolic process |
| cholesterol metabolic process |
| lipoprotein metabolic process |
| terpenoid metabolic process |
| organophosphate ester transport |
| steroid biosynthetic process |
| detoxification |
| secondary alcohol metabolic process |
| cellular response to reactive oxygen species |
| lipid homeostasis |
| sterol metabolic process |
| regulation of lipid localization |
| positive regulation of small molecule metabolic process |
| organic hydroxy compound transport |
| isoprenoid metabolic process |
| positive regulation of lipid metabolic process |
| blood microparticle |
| drug catabolic process |
| lipid binding |
| regulation of cellular ketone metabolic process |
| organic hydroxy compound biosynthetic process |
| regulation of lipid biosynthetic process |
| ammonium ion metabolic process |
| cellular lipid catabolic process |
| response to reactive oxygen species |
| cellular response to toxic substance |
| cellular response to oxidative stress |
| early endosome |
| steroid metabolic process |
| lipid transport |
| lipid catabolic process |
| endoplasmic reticulum lumen |
| glycerophospholipid metabolic process |
| alcohol metabolic process |
| lipid localization |
| collagen-containing extracellular matrix |
| positive regulation of cellular catabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| extracellular structure organization |
| response to oxidative stress |
| regulation of lipid metabolic process |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| cofactor metabolic process |
| organic hydroxy compound metabolic process |
| organic anion transport |
| drug metabolic process |
| cell-cell adhesion |
| response to toxic substance |
| response to inorganic substance |
| lipid biosynthetic process |
| anion transport |
| regulation of system process |
| small molecule biosynthetic process |
| cell surface |
| negative regulation of cellular component organization |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of cellular catabolic process |
| protein homodimerization activity |
| organophosphate metabolic process |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| cellular lipid metabolic process |
| regulation of catabolic process |
| cellular response to oxygen-containing compound |
| identical protein binding |
| chemical homeostasis |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| regulation of hydrolase activity |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| positive regulation of catalytic activity |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| extracellular space |
| homeostatic process |
| cellular response to stress |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mitomycin-C 0.06μM R08 exp503 | -2.12 |
| Amiloride 100μM R08 exp447 | -2.09 |
| Campthothecin 0.001μM R06 exp270 | 1.78 |
| Cannabidiol 20μM R08 exp466 | 1.81 |
| D-Fructose 10000μM R06 exp279 | 2.03 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17783
- Expression level (log2 read counts): -7.68
Expression Distribution
APOA4 Expression in NALM6 Cells: -7.68
