APOBEC1 [The Human Chemical-Genetic Interaction Map Project]

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======= APOBEC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOBEC1
  * **<color #00a2e8>Official Name</color>**: apolipoprotein B mRNA editing enzyme catalytic subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=339|339]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41238|P41238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOBEC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOBEC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:11727199}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APOBEC C|
|APOBEC N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosine deaminase activity|
|positive regulation of mRNA modification|
|regulation of mRNA modification|
|negative regulation of methylation-dependent chromatin silencing|
|DNA cytosine deamination|
|negative regulation of triglyceride metabolic process|
|cytidine to uridine editing|
|cytidine deaminase activity|
|lipoprotein localization|
|cytidine deamination|
|cytidine catabolic process|
|cytidine metabolic process|
|lipoprotein transport|
|DNA deamination|
|pyrimidine ribonucleoside catabolic process|
|regulation of methylation-dependent chromatin silencing|
|pyrimidine ribonucleoside metabolic process|
|DNA demethylation|
|negative regulation of chromatin silencing|
|base conversion or substitution editing|
|mRNA modification|
|pyrimidine nucleoside catabolic process|
|ribonucleoside catabolic process|
|DNA dealkylation|
|mRNA 3-UTR AU-rich region binding|
|ribonucleoprotein complex binding|
|regulation of triglyceride metabolic process|
|nucleoside catabolic process|
|negative regulation of gene silencing|
|pyrimidine nucleoside metabolic process|
|regulation of chromatin silencing|
|mRNA stabilization|
|pyrimidine-containing compound catabolic process|
|glycosyl compound catabolic process|
|enzyme activator activity|
|RNA stabilization|
|nucleobase-containing small molecule catabolic process|
|negative regulation of mRNA catabolic process|
|response to zinc ion|
|response to gamma radiation|
|negative regulation of RNA catabolic process|
|negative regulation of chromatin organization|
|positive regulation of gene expression, epigenetic|
|demethylation|
|DNA methylation or demethylation|
|triglyceride metabolic process|
|ribonucleoside metabolic process|
|response to osmotic stress|
|positive regulation of mRNA metabolic process|
|negative regulation of mRNA metabolic process|
|negative regulation of lipid metabolic process|
|DNA modification|
|lipoprotein biosynthetic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|lipoprotein metabolic process|
|response to ethanol|
|regulation of gene silencing|
|negative regulation of chromosome organization|
|glycosyl compound metabolic process|
|response to ionizing radiation|
|response to calcium ion|
|cellular response to insulin stimulus|
|RNA modification|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of chromatin organization|
|defense response to virus|
|carbohydrate derivative catabolic process|
|regulation of mRNA catabolic process|
|response to insulin|
|response to alcohol|
|regulation of gene expression, epigenetic|
|protein domain specific binding|
|negative regulation of cellular catabolic process|
|cellular response to peptide hormone stimulus|
|response to virus|
|response to antibiotic|
|negative regulation of catabolic process|
|cellular response to peptide|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|response to metal ion|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|response to radiation|
|aromatic compound catabolic process|
|response to peptide|
|mRNA processing|
|organic cyclic compound catabolic process|
|response to toxic substance|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|DNA metabolic process|
|regulation of cellular catabolic process|
|zinc ion binding|
|RNA processing|
|response to hormone|
|defense response to other organism|
|cellular lipid metabolic process|
|regulation of catabolic process|
|response to organonitrogen compound|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|immune effector process|
|response to abiotic stimulus|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|RNA binding|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.78|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOBEC1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>