APOBEC1
Gene Information
- Official Symbol: APOBEC1
- Official Name: apolipoprotein B mRNA editing enzyme catalytic subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 339
- UniProt: P41238
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:11727199}.
Pfam Domains GO Terms
Pfam Domains
| APOBEC C |
| APOBEC N |
GO Terms
| cytosine deaminase activity |
| positive regulation of mRNA modification |
| regulation of mRNA modification |
| negative regulation of methylation-dependent chromatin silencing |
| DNA cytosine deamination |
| negative regulation of triglyceride metabolic process |
| cytidine to uridine editing |
| cytidine deaminase activity |
| lipoprotein localization |
| cytidine deamination |
| cytidine catabolic process |
| cytidine metabolic process |
| lipoprotein transport |
| DNA deamination |
| pyrimidine ribonucleoside catabolic process |
| regulation of methylation-dependent chromatin silencing |
| pyrimidine ribonucleoside metabolic process |
| DNA demethylation |
| negative regulation of chromatin silencing |
| base conversion or substitution editing |
| mRNA modification |
| pyrimidine nucleoside catabolic process |
| ribonucleoside catabolic process |
| DNA dealkylation |
| mRNA 3-UTR AU-rich region binding |
| ribonucleoprotein complex binding |
| regulation of triglyceride metabolic process |
| nucleoside catabolic process |
| negative regulation of gene silencing |
| pyrimidine nucleoside metabolic process |
| regulation of chromatin silencing |
| mRNA stabilization |
| pyrimidine-containing compound catabolic process |
| glycosyl compound catabolic process |
| enzyme activator activity |
| RNA stabilization |
| nucleobase-containing small molecule catabolic process |
| negative regulation of mRNA catabolic process |
| response to zinc ion |
| response to gamma radiation |
| negative regulation of RNA catabolic process |
| negative regulation of chromatin organization |
| positive regulation of gene expression, epigenetic |
| demethylation |
| DNA methylation or demethylation |
| triglyceride metabolic process |
| ribonucleoside metabolic process |
| response to osmotic stress |
| positive regulation of mRNA metabolic process |
| negative regulation of mRNA metabolic process |
| negative regulation of lipid metabolic process |
| DNA modification |
| lipoprotein biosynthetic process |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| pyrimidine-containing compound metabolic process |
| nucleoside metabolic process |
| lipoprotein metabolic process |
| response to ethanol |
| regulation of gene silencing |
| negative regulation of chromosome organization |
| glycosyl compound metabolic process |
| response to ionizing radiation |
| response to calcium ion |
| cellular response to insulin stimulus |
| RNA modification |
| regulation of mRNA stability |
| regulation of RNA stability |
| regulation of chromatin organization |
| defense response to virus |
| carbohydrate derivative catabolic process |
| regulation of mRNA catabolic process |
| response to insulin |
| response to alcohol |
| regulation of gene expression, epigenetic |
| protein domain specific binding |
| negative regulation of cellular catabolic process |
| cellular response to peptide hormone stimulus |
| response to virus |
| response to antibiotic |
| negative regulation of catabolic process |
| cellular response to peptide |
| regulation of mRNA metabolic process |
| regulation of chromosome organization |
| response to metal ion |
| negative regulation of organelle organization |
| nucleobase-containing compound catabolic process |
| glycerolipid metabolic process |
| response to peptide hormone |
| regulation of lipid metabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| small molecule catabolic process |
| response to radiation |
| aromatic compound catabolic process |
| response to peptide |
| mRNA processing |
| organic cyclic compound catabolic process |
| response to toxic substance |
| posttranscriptional regulation of gene expression |
| response to inorganic substance |
| nucleobase-containing small molecule metabolic process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| mRNA metabolic process |
| negative regulation of cellular component organization |
| DNA metabolic process |
| regulation of cellular catabolic process |
| zinc ion binding |
| RNA processing |
| response to hormone |
| defense response to other organism |
| cellular lipid metabolic process |
| regulation of catabolic process |
| response to organonitrogen compound |
| response to drug |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| immune effector process |
| response to abiotic stimulus |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| RNA binding |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| response to endogenous stimulus |
| protein transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| amide transport |
| establishment of protein localization |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Benzoate 10000μM R08 exp455 | 1.78 |
| Nocodazole 0.2μM R00 exp24 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6140
- Expression level (log2 read counts): -7.68
Expression Distribution
APOBEC1 Expression in NALM6 Cells: -7.68
