APOBEC3H

Entrez Summary: N/A
UniProt Summary: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H- var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:16571802, ECO:0000269|PubMed:16920826, ECO:0000269|PubMed:18299330, ECO:0000269|PubMed:18779051, ECO:0000269|PubMed:18827027, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23097438}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

APOBEC C
APOBEC N

DNA cytosine deamination
cytidine catabolic process
cytidine metabolic process
cytidine deamination
cytidine to uridine editing
cytidine deaminase activity
pyrimidine ribonucleoside catabolic process
DNA deamination
pyrimidine ribonucleoside metabolic process
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
regulation of single stranded viral RNA replication via double stranded DNA intermediate
DNA demethylation
base conversion or substitution editing
ribonucleoside catabolic process
regulation of transposition
negative regulation of transposition
pyrimidine nucleoside catabolic process
DNA dealkylation
nucleoside catabolic process
pyrimidine nucleoside metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
negative regulation of viral genome replication
demethylation
DNA methylation or demethylation
ribonucleoside metabolic process
negative regulation of viral life cycle
P-body
DNA modification
regulation of viral genome replication
negative regulation of viral process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
regulation of viral life cycle
RNA modification
carbohydrate derivative catabolic process
defense response to virus
regulation of viral process