APOBR

Entrez Summary: N/A
UniProt Summary: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:10852956, ECO:0000269|PubMed:15591219, ECO:0000269|PubMed:9633939}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Etoposide 0.3μM R05 exp199	-1.84
Trametinib 10μM R02 exp83	1.75

very-low-density lipoprotein particle receptor activity
very-low-density lipoprotein particle clearance
chylomicron
low-density lipoprotein particle
very-low-density lipoprotein particle
plasma lipoprotein particle clearance
regulation of plasma lipoprotein particle levels
triglyceride metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
cholesterol metabolic process
secondary alcohol metabolic process
sterol metabolic process
steroid metabolic process
lipid transport
alcohol metabolic process
lipid localization
glycerolipid metabolic process
organic hydroxy compound metabolic process
endocytosis
import into cell
cellular lipid metabolic process
lipid metabolic process
small molecule metabolic process
vesicle-mediated transport
membrane