APOM [The Human Chemical-Genetic Interaction Map Project]

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======= APOM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOM
  * **<color #00a2e8>Official Name</color>**: apolipoprotein M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55937|55937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95445|O95445]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. {ECO:0000269|PubMed:17525477, ECO:0000269|PubMed:19733574}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ApoM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of plasma lipoprotein oxidation|
|discoidal high-density lipoprotein particle|
|regulation of plasma lipoprotein oxidation|
|spherical high-density lipoprotein particle|
|high-density lipoprotein particle clearance|
|high-density lipoprotein particle assembly|
|low-density lipoprotein particle|
|reverse cholesterol transport|
|high-density lipoprotein particle remodeling|
|antioxidant activity|
|very-low-density lipoprotein particle|
|high-density lipoprotein particle|
|cholesterol efflux|
|plasma lipoprotein particle assembly|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|protein-lipid complex assembly|
|lipid transporter activity|
|plasma lipoprotein particle clearance|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|cholesterol transport|
|sterol transport|
|regulation of plasma lipoprotein particle levels|
|cholesterol homeostasis|
|sterol homeostasis|
|cellular oxidant detoxification|
|cellular detoxification|
|retinoid metabolic process|
|phospholipid binding|
|diterpenoid metabolic process|
|lipoprotein metabolic process|
|terpenoid metabolic process|
|detoxification|
|lipid homeostasis|
|isoprenoid metabolic process|
|response to glucose|
|organic hydroxy compound transport|
|response to hexose|
|response to monosaccharide|
|response to carbohydrate|
|cellular response to toxic substance|
|lipid transport|
|lipid localization|
|extracellular structure organization|
|response to toxic substance|
|negative regulation of cellular component organization|
|cellular lipid metabolic process|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.07|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.72|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.8|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16682
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOM Expression in NALM6 Cells: 1.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>