APOPT1

Gene Information

Official Symbol: COA8
Official Name: cytochrome c oxidase assembly factor 8
Aliases and Previous Symbols: N/A
Entrez ID: 84334
UniProt: Q96IL0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade. {ECO:0000250|UniProtKB:Q9CQW7}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8328
Expression level (log2 read counts): 4.33

Expression Distribution

positive regulation of smooth muscle cell apoptotic process
regulation of smooth muscle cell apoptotic process
positive regulation of muscle cell apoptotic process
positive regulation of release of cytochrome c from mitochondria
regulation of release of cytochrome c from mitochondria
regulation of muscle cell apoptotic process
positive regulation of mitochondrion organization
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
positive regulation of proteolysis
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
apoptotic process
programmed cell death
cell death
positive regulation of cellular component organization
mitochondrion
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
regulation of cell death