APP
Gene Information
- Official Symbol: APP
- Official Name: amyloid beta precursor protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 351
- UniProt: P05067
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| APP E2 |
| Kunitz BPTI |
| APP Cu bd |
| Beta-APP |
| APP N |
| APP amyloid |
GO Terms
| cellular response to norepinephrine stimulus |
| collateral sprouting in absence of injury |
| signaling receptor activator activity |
| smooth endoplasmic reticulum calcium ion homeostasis |
| negative regulation of low-density lipoprotein receptor activity |
| response to norepinephrine |
| growth cone lamellipodium |
| PTB domain binding |
| positive regulation of amyloid fibril formation |
| microglia development |
| growth factor receptor binding |
| growth cone filopodium |
| microglia differentiation |
| astrocyte activation involved in immune response |
| axon midline choice point recognition |
| synaptic growth at neuromuscular junction |
| regulation of spontaneous synaptic transmission |
| axon choice point recognition |
| positive regulation of interleukin-1 beta biosynthetic process |
| regulation of interleukin-1 beta biosynthetic process |
| astrocyte projection |
| positive regulation of interleukin-1 biosynthetic process |
| tumor necrosis factor production |
| main axon |
| regulation of interleukin-1 biosynthetic process |
| regulation of amyloid fibril formation |
| tumor necrosis factor superfamily cytokine production |
| amyloid fibril formation |
| modulation of age-related behavioral decline |
| collateral sprouting |
| nuclear envelope lumen |
| ciliary rootlet |
| neuron projection maintenance |
| peptidase activator activity |
| neuron remodeling |
| negative regulation of long-term synaptic potentiation |
| positive regulation of chemokine biosynthetic process |
| cellular response to manganese ion |
| suckling behavior |
| cellular copper ion homeostasis |
| positive regulation of interleukin-6 biosynthetic process |
| positive regulation of amyloid-beta formation |
| regulation of chemokine biosynthetic process |
| Golgi-associated vesicle |
| copper ion homeostasis |
| endosome lumen |
| positive regulation of amyloid precursor protein catabolic process |
| astrocyte activation |
| response to manganese ion |
| transition metal ion binding |
| positive regulation of tumor necrosis factor biosynthetic process |
| mating behavior |
| positive regulation of long-term synaptic potentiation |
| endoplasmic reticulum calcium ion homeostasis |
| positive regulation of glycolytic process |
| regulation of interleukin-6 biosynthetic process |
| response to lead ion |
| macrophage differentiation |
| spindle midzone |
| ionotropic glutamate receptor signaling pathway |
| regulation of amyloid-beta formation |
| smooth endoplasmic reticulum |
| regulation of epidermal growth factor-activated receptor activity |
| regulation of long-term neuronal synaptic plasticity |
| positive regulation of G2/M transition of mitotic cell cycle |
| mRNA polyadenylation |
| positive regulation of peptidyl-threonine phosphorylation |
| regulation of presynapse assembly |
| reproductive behavior |
| leukocyte activation involved in inflammatory response |
| positive regulation of cell cycle G2/M phase transition |
| RNA polyadenylation |
| microglial cell activation |
| regulation of tumor necrosis factor biosynthetic process |
| regulation of presynapse organization |
| cellular response to copper ion |
| positive regulation of T cell migration |
| mating |
| regulation of amyloid precursor protein catabolic process |
| presynaptic active zone |
| astrocyte development |
| regulation of NMDA receptor activity |
| dendritic shaft |
| positive regulation of lymphocyte migration |
| neuron maturation |
| glial cell activation |
| cellular response to amyloid-beta |
| neuron projection organization |
| modulation of excitatory postsynaptic potential |
| neuroinflammatory response |
| neuromuscular junction development |
| COPII-coated ER to Golgi transport vesicle |
| regulation of peptidyl-threonine phosphorylation |
| regulation of T cell migration |
| neuron apoptotic process |
| negative regulation of endocytosis |
| regulation of long-term synaptic potentiation |
| glutamate receptor signaling pathway |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of nucleotide metabolic process |
| positive regulation of ATP metabolic process |
| response to copper ion |
| neuron recognition |
| visual learning |
| response to amyloid-beta |
| cellular response to nerve growth factor stimulus |
| macrophage activation |
| positive regulation of interleukin-1 beta production |
| response to nerve growth factor |
| neuromuscular process controlling balance |
| neuron death |
| astrocyte differentiation |
| regulation of neuronal synaptic plasticity |
| visual behavior |
| clathrin-coated pit |
| cellular response to cAMP |
| positive regulation of chemokine production |
| positive regulation of interleukin-1 production |
| myeloid cell development |
| rough endoplasmic reticulum |
| regulation of lymphocyte migration |
| regulation of glutamate receptor signaling pathway |
| regulation of multicellular organism growth |
| axo-dendritic transport |
| positive regulation of cytokine biosynthetic process |
| platelet alpha granule lumen |
| multi-organism behavior |
| apical part of cell |
| regulation of neurotransmitter receptor activity |
| adult locomotory behavior |
| neuromuscular junction |
| positive regulation of NIK/NF-kappaB signaling |
| positive regulation of mitotic cell cycle phase transition |
| associative learning |
| regulation of chemokine production |
| regulation of glycolytic process |
| positive regulation of carbohydrate metabolic process |
| regulation of interleukin-1 beta production |
| mRNA 3-end processing |
| regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of tumor necrosis factor production |
| feeding behavior |
| developmental cell growth |
| regulation of carbohydrate catabolic process |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of protein tyrosine kinase activity |
| cell growth |
| regulation of ERBB signaling pathway |
| trans-Golgi network membrane |
| positive regulation of cell cycle phase transition |
| positive regulation of protein binding |
| synapse assembly |
| positive regulation of interleukin-6 production |
| regulation of interleukin-1 production |
| serine-type endopeptidase inhibitor activity |
| response to cAMP |
| Golgi lumen |
| cellular response to catecholamine stimulus |
| cellular response to monoamine stimulus |
| dendrite development |
| regulation of synapse assembly |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of cytokine biosynthetic process |
| response to catecholamine |
| response to monoamine |
| glial cell development |
| cellular transition metal ion homeostasis |
| neuromuscular process |
| regulation of NIK/NF-kappaB signaling |
| myeloid leukocyte differentiation |
| developmental growth involved in morphogenesis |
| regulation of purine nucleotide metabolic process |
| recycling endosome |
| cholesterol metabolic process |
| regulation of nucleotide metabolic process |
| synaptic vesicle |
| regulation of ATP metabolic process |
| Notch signaling pathway |
| platelet degranulation |
| secondary alcohol metabolic process |
| positive regulation of leukocyte migration |
| transition metal ion homeostasis |
| perikaryon |
| sterol metabolic process |
| anatomical structure maturation |
| RNA 3-end processing |
| response to organophosphorus |
| regulation of nervous system process |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of small molecule metabolic process |
| positive regulation of JNK cascade |
| regulation of interleukin-6 production |
| adult behavior |
| learning |
| regulation of tumor necrosis factor production |
| dendritic spine |
| cytokine production |
| positive regulation of cellular amide metabolic process |
| positive regulation of synaptic transmission |
| positive regulation of mitotic cell cycle |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of tumor necrosis factor superfamily cytokine production |
| response to purine-containing compound |
| transport along microtubule |
| cell maturation |
| regulation of generation of precursor metabolites and energy |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| glial cell differentiation |
| heparin binding |
| cell-cell junction |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| cytoskeleton-dependent intracellular transport |
| positive regulation of binding |
| microtubule-based transport |
| regulation of JNK cascade |
| regulation of synaptic plasticity |
| positive regulation of peptidase activity |
| cellular response to metal ion |
| locomotory behavior |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of leukocyte migration |
| positive regulation of supramolecular fiber organization |
| response to interleukin-1 |
| receptor complex |
| regulation of carbohydrate metabolic process |
| regulation of endocytosis |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cell cycle G2/M phase transition |
| gliogenesis |
| regulation of synapse organization |
| regulation of protein binding |
| cellular response to inorganic substance |
| myeloid cell differentiation |
| membrane raft |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| cell recognition |
| developmental maturation |
| negative regulation of endopeptidase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of peptidase activity |
| early endosome |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| axon guidance |
| steroid metabolic process |
| neuron projection guidance |
| positive regulation of DNA-binding transcription factor activity |
| regulation of transmembrane transporter activity |
| synapse |
| endosome |
| synapse organization |
| microtubule-based movement |
| regulation of transporter activity |
| aging |
| positive regulation of cell cycle process |
| negative regulation of neurogenesis |
| regulation of ERK1 and ERK2 cascade |
| axon |
| cognition |
| endoplasmic reticulum lumen |
| response to light stimulus |
| negative regulation of nervous system development |
| alcohol metabolic process |
| cellular response to peptide |
| regulation of developmental growth |
| leukocyte differentiation |
| regulation of cation transmembrane transport |
| negative regulation of cell development |
| signaling receptor binding |
| extracellular matrix organization |
| enzyme binding |
| regulation of supramolecular fiber organization |
| negative regulation of proteolysis |
| regulation of translation |
| positive regulation of proteolysis |
| regulation of Wnt signaling pathway |
| post-translational protein modification |
| positive regulation of cellular catabolic process |
| response to metal ion |
| axonogenesis |
| positive regulation of cell cycle |
| regulation of binding |
| response to oxidative stress |
| forebrain development |
| extracellular structure organization |
| developmental growth |
| growth |
| regulation of cellular amide metabolic process |
| axon development |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of DNA-binding transcription factor activity |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of catabolic process |
| cellular calcium ion homeostasis |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| calcium ion homeostasis |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| organic hydroxy compound metabolic process |
| supramolecular fiber organization |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| mRNA processing |
| regulation of ion transmembrane transport |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| cell projection morphogenesis |
| inflammatory response |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| cell part morphogenesis |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| response to growth factor |
| response to inorganic substance |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| endocytosis |
| cell morphogenesis involved in differentiation |
| hemopoiesis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| behavior |
| myeloid leukocyte activation |
| regulation of system process |
| cellular response to organonitrogen compound |
| hematopoietic or lymphoid organ development |
| cell surface |
| metal ion homeostasis |
| cell activation involved in immune response |
| regulation of mitotic cell cycle |
| cellular cation homeostasis |
| cellular ion homeostasis |
| immune system development |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| neuron projection development |
| microtubule-based process |
| regulation of growth |
| negative regulation of cell population proliferation |
| import into cell |
| regulation of cytokine production |
| mRNA metabolic process |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| cation homeostasis |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| brain development |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| innate immune response |
| positive regulation of hydrolase activity |
| head development |
| ion homeostasis |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| regulation of cell migration |
| regulation of kinase activity |
| RNA processing |
| cellular homeostasis |
| regulation of cell motility |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| defense response to other organism |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| Golgi apparatus |
| multi-organism reproductive process |
| regulation of catabolic process |
| regulation of cellular component movement |
| response to organonitrogen compound |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| export from cell |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| cell death |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| cell projection organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| nervous system process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| DNA binding |
| response to endogenous stimulus |
| regulation of response to stress |
| intracellular transport |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bleomycin 5μM R08 exp459 | 1.89 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12932
- Expression level (log2 read counts): 8.89
Expression Distribution
APP Expression in NALM6 Cells: 8.89
