APRT [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= APRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APRT
  * **<color #00a2e8>Official Name</color>**: adenine phosphoribosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=353|353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07741|P07741]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pribosyltran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenine binding|
|adenine phosphoribosyltransferase activity|
|adenine salvage|
|AMP salvage|
|adenine biosynthetic process|
|adenine metabolic process|
|purine nucleobase salvage|
|purine ribonucleoside salvage|
|AMP biosynthetic process|
|purine nucleotide salvage|
|purine nucleobase biosynthetic process|
|AMP binding|
|AMP metabolic process|
|grooming behavior|
|nucleotide salvage|
|purine-containing compound salvage|
|nucleoside salvage|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|purine nucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|ribonucleoside monophosphate biosynthetic process|
|cellular metabolic compound salvage|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside biosynthetic process|
|nucleobase metabolic process|
|glycosyl compound biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|lactation|
|pigment biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|pigment metabolic process|
|nucleoside monophosphate metabolic process|
|body fluid secretion|
|ribonucleoside metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|secretory granule lumen|
|mammary gland development|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular response to insulin stimulus|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to insulin|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular response to peptide hormone stimulus|
|purine ribonucleotide metabolic process|
|cellular response to peptide|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|response to peptide hormone|
|gland development|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|behavior|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|response to hormone|
|leukocyte activation|
|response to organonitrogen compound|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.95|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.88|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.79|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf93|C14orf93]]|0.483|
|[[:human genes:m:med12|MED12]]|0.455|
|[[:human genes:t:tfip11|TFIP11]]|0.444|
|[[:human genes:k:kctd17|KCTD17]]|0.435|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.433|
|[[:human genes:n:nup54|NUP54]]|0.425|
|[[:human genes:c:cbwd3|CBWD3]]|0.418|
|[[:human genes:e:egr2|EGR2]]|0.418|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.414|
|[[:human genes:a:akirin2|AKIRIN2]]|0.41|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.41|
|[[:human genes:r:rbbp5|RBBP5]]|0.407|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.405|
|[[:human genes:c:cdc6|CDC6]]|0.404|
|[[:human genes:s:sec13|SEC13]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APRT Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>