APRT

• Official Symbol: APRT
• Official Name: adenine phosphoribosyltransferase
• Aliases and Previous Symbols: N/A
• Entrez ID: 353
• UniProt: P07741
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
• UniProt Summary: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 2197
• Expression level (log2 read counts): 5.23

Expression Distribution

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APRT Expression in NALM6 Cells: 5.23