AQP7
Gene Information
- Official Symbol: AQP7
- Official Name: aquaporin 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 364
- UniProt: O14520
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015].
- UniProt Summary: Forms a channel for water and glycerol.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3625
- Expression level (log2 read counts): -0.19
AQP7 Expression in NALM6 Cells: -0.19
