ARAF [The Human Chemical-Genetic Interaction Map Project]

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======= ARAF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARAF
  * **<color #00a2e8>Official Name</color>**: A-Raf proto-oncogene, serine/threonine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=369|369]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10398|P10398]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARAF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARAF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/311010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. {ECO:0000269|PubMed:22609986}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|Pkinase Tyr|
|Pkinase|
|RBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of TOR signaling|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of peptidyl-serine phosphorylation|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|protein kinase activity|
|regulation of cellular protein catabolic process|
|protein serine/threonine kinase activity|
|MAPK cascade|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|cellular component|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|protein phosphorylation|
|regulation of catabolic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.71|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.7|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16357
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARAF Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>