ARAF

Gene Information

Official Symbol: ARAF
Official Name: A-Raf proto-oncogene, serine/threonine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 369
UniProt: P10398
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012].
UniProt Summary: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. {ECO:0000269|PubMed:22609986}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16357
Expression level (log2 read counts): 5.54

Expression Distribution

Screen	Score
Cyclosporin-A 0.8μM R07 exp347	-1.71
GW501516 25μM R06 exp285	-1.7
UM0011500 5μM R05 exp245	1.88

C1 1
Pkinase Tyr
Pkinase
RBD

regulation of TOR signaling
positive regulation of peptidyl-serine phosphorylation
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of peptidyl-serine phosphorylation
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
protein kinase activity
regulation of cellular protein catabolic process
protein serine/threonine kinase activity
MAPK cascade
regulation of protein catabolic process
signal transduction by protein phosphorylation
cellular component
regulation of proteolysis
regulation of cellular catabolic process
negative regulation of apoptotic process
negative regulation of programmed cell death
protein phosphorylation
regulation of catabolic process
negative regulation of cell death
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
mitochondrion
phosphorylation
regulation of protein phosphorylation
ATP binding
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
positive regulation of cellular protein metabolic process
regulation of cell death
intracellular signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction