ARC [The Human Chemical-Genetic Interaction Map Project]

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======= ARC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARC
  * **<color #00a2e8>Official Name</color>**: activity regulated cytoskeleton associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23237|23237]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7LC44|Q7LC44]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269|PubMed:21834987}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle-mediated intercellular transport|
|postsynaptic endosome|
|intercellular transport|
|positive regulation of AMPA receptor activity|
|regulation of postsynaptic neurotransmitter receptor internalization|
|regulation of long-term synaptic depression|
|positive regulation of glutamate receptor signaling pathway|
|dendritic spine morphogenesis|
|postsynaptic density membrane|
|regulation of AMPA receptor activity|
|dendritic spine development|
|dendritic spine organization|
|long-term memory|
|positive regulation of signaling receptor activity|
|neuron projection organization|
|regulation of dendritic spine morphogenesis|
|regulation of long-term synaptic potentiation|
|long-term synaptic potentiation|
|regulation of neuronal synaptic plasticity|
|regulation of receptor internalization|
|extracellular vesicle|
|dendrite morphogenesis|
|regulation of glutamate receptor signaling pathway|
|positive regulation of cation channel activity|
|regulation of dendritic spine development|
|endoderm development|
|regulation of neurotransmitter receptor activity|
|acrosomal vesicle|
|postsynapse organization|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|regulation of receptor-mediated endocytosis|
|dendrite development|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|memory|
|cell cortex|
|positive regulation of cation transmembrane transport|
|learning|
|dendritic spine|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|early endosome membrane|
|positive regulation of ion transmembrane transport|
|mRNA transport|
|mRNA binding|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of synaptic plasticity|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|anterior/posterior pattern specification|
|actin cytoskeleton|
|RNA localization|
|regulation of synapse organization|
|membrane raft|
|regulation of synapse structure or activity|
|nucleobase-containing compound transport|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regionalization|
|regulation of cation transmembrane transport|
|protein homooligomerization|
|glutamatergic synapse|
|neuronal cell body|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|protein complex oligomerization|
|regulation of cellular protein localization|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|behavior|
|regulation of neuron differentiation|
|neuron projection development|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of protein transport|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of transport|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>