ARC
Gene Information
- Official Symbol: ARC
- Official Name: activity regulated cytoskeleton associated protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 23237
- UniProt: Q7LC44
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| vesicle-mediated intercellular transport |
| postsynaptic endosome |
| intercellular transport |
| positive regulation of AMPA receptor activity |
| regulation of postsynaptic neurotransmitter receptor internalization |
| regulation of long-term synaptic depression |
| positive regulation of glutamate receptor signaling pathway |
| dendritic spine morphogenesis |
| postsynaptic density membrane |
| regulation of AMPA receptor activity |
| dendritic spine development |
| dendritic spine organization |
| long-term memory |
| positive regulation of signaling receptor activity |
| neuron projection organization |
| regulation of dendritic spine morphogenesis |
| regulation of long-term synaptic potentiation |
| long-term synaptic potentiation |
| regulation of neuronal synaptic plasticity |
| regulation of receptor internalization |
| extracellular vesicle |
| dendrite morphogenesis |
| regulation of glutamate receptor signaling pathway |
| positive regulation of cation channel activity |
| regulation of dendritic spine development |
| endoderm development |
| regulation of neurotransmitter receptor activity |
| acrosomal vesicle |
| postsynapse organization |
| regulation of dendrite morphogenesis |
| regulation of postsynapse organization |
| regulation of receptor-mediated endocytosis |
| dendrite development |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| memory |
| cell cortex |
| positive regulation of cation transmembrane transport |
| learning |
| dendritic spine |
| regulation of dendrite development |
| positive regulation of synaptic transmission |
| early endosome membrane |
| positive regulation of ion transmembrane transport |
| mRNA transport |
| mRNA binding |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| regulation of synaptic plasticity |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| positive regulation of transmembrane transport |
| regulation of endocytosis |
| anterior/posterior pattern specification |
| actin cytoskeleton |
| RNA localization |
| regulation of synapse organization |
| membrane raft |
| regulation of synapse structure or activity |
| nucleobase-containing compound transport |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| regulation of transmembrane transporter activity |
| synapse organization |
| positive regulation of ion transport |
| regulation of transporter activity |
| cognition |
| regulation of cell morphogenesis involved in differentiation |
| regionalization |
| regulation of cation transmembrane transport |
| protein homooligomerization |
| glutamatergic synapse |
| neuronal cell body |
| cell morphogenesis involved in neuron differentiation |
| pattern specification process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of ion transmembrane transport |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| protein complex oligomerization |
| regulation of cellular protein localization |
| cell junction |
| regulation of vesicle-mediated transport |
| endocytosis |
| cell morphogenesis involved in differentiation |
| regulation of transmembrane transport |
| behavior |
| regulation of neuron differentiation |
| neuron projection development |
| import into cell |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| regulation of protein transport |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| cell migration |
| positive regulation of transport |
| neuron differentiation |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| locomotion |
| nervous system process |
| generation of neurons |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14907
- Expression level (log2 read counts): -7.68
Expression Distribution
ARC Expression in NALM6 Cells: -7.68
