AREG [The Human Chemical-Genetic Interaction Map Project]

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======= AREG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AREG
  * **<color #00a2e8>Official Name</color>**: amphiregulin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=374|374]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15514|P15514]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AREG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AREG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis|
|epithelial cell proliferation involved in mammary gland duct elongation|
|thelarche|
|branch elongation involved in mammary gland duct branching|
|mammary gland branching involved in thelarche|
|development of secondary female sexual characteristics|
|development of secondary sexual characteristics|
|dichotomous subdivision of an epithelial terminal unit|
|positive regulation of keratinocyte proliferation|
|mammary gland epithelial cell proliferation|
|glial cell proliferation|
|branch elongation of an epithelium|
|mammary gland alveolus development|
|mammary gland lobule development|
|branching involved in mammary gland duct morphogenesis|
|axis elongation|
|mammary gland duct morphogenesis|
|epidermal growth factor receptor binding|
|regulation of keratinocyte proliferation|
|negative regulation of osteoblast differentiation|
|mammary gland morphogenesis|
|negative regulation of epidermal growth factor receptor signaling pathway|
|epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|clathrin-coated vesicle membrane|
|ER to Golgi transport vesicle membrane|
|mammary gland epithelium development|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting, to, from or within Golgi|
|ERBB signaling pathway|
|negative regulation of ossification|
|Golgi vesicle budding|
|regulation of epidermal growth factor receptor signaling pathway|
|epithelial cell proliferation|
|vesicle targeting|
|regulation of ERBB signaling pathway|
|vesicle budding from membrane|
|gland morphogenesis|
|response to cAMP|
|regulation of osteoblast differentiation|
|developmental growth involved in morphogenesis|
|response to hydrogen peroxide|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|response to organophosphorus|
|response to estradiol|
|response to glucocorticoid|
|response to purine-containing compound|
|morphogenesis of a branching epithelium|
|response to corticosteroid|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|morphogenesis of a branching structure|
|cytokine activity|
|establishment of vesicle localization|
|vesicle localization|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of ossification|
|response to reactive oxygen species|
|gliogenesis|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein kinase B signaling|
|regulation of peptidyl-tyrosine phosphorylation|
|vesicle organization|
|response to antibiotic|
|epithelial tube morphogenesis|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|establishment of organelle localization|
|MAPK cascade|
|Golgi vesicle transport|
|response to oxidative stress|
|developmental growth|
|response to peptide hormone|
|growth|
|signal transduction by protein phosphorylation|
|gland development|
|morphogenesis of an epithelium|
|response to peptide|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to inorganic substance|
|cell population proliferation|
|tissue morphogenesis|
|organelle localization|
|cell surface|
|Golgi membrane|
|tube morphogenesis|
|neuron projection development|
|developmental process involved in reproduction|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|neuron development|
|tube development|
|response to lipid|
|membrane organization|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.45|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14952
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AREG Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>