AREG
Gene Information
- Official Symbol: AREG
- Official Name: amphiregulin
- Aliases and Previous Symbols: N/A
- Entrez ID: 374
- UniProt: P15514
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis |
| epithelial cell proliferation involved in mammary gland duct elongation |
| thelarche |
| branch elongation involved in mammary gland duct branching |
| mammary gland branching involved in thelarche |
| development of secondary female sexual characteristics |
| development of secondary sexual characteristics |
| dichotomous subdivision of an epithelial terminal unit |
| positive regulation of keratinocyte proliferation |
| mammary gland epithelial cell proliferation |
| glial cell proliferation |
| branch elongation of an epithelium |
| mammary gland alveolus development |
| mammary gland lobule development |
| branching involved in mammary gland duct morphogenesis |
| axis elongation |
| mammary gland duct morphogenesis |
| epidermal growth factor receptor binding |
| regulation of keratinocyte proliferation |
| negative regulation of osteoblast differentiation |
| mammary gland morphogenesis |
| negative regulation of epidermal growth factor receptor signaling pathway |
| epidermal growth factor receptor signaling pathway |
| negative regulation of ERBB signaling pathway |
| clathrin-coated vesicle membrane |
| ER to Golgi transport vesicle membrane |
| mammary gland epithelium development |
| COPII vesicle coating |
| vesicle targeting, rough ER to cis-Golgi |
| vesicle coating |
| COPII-coated vesicle budding |
| endoplasmic reticulum-Golgi intermediate compartment membrane |
| vesicle targeting, to, from or within Golgi |
| ERBB signaling pathway |
| negative regulation of ossification |
| Golgi vesicle budding |
| regulation of epidermal growth factor receptor signaling pathway |
| epithelial cell proliferation |
| vesicle targeting |
| regulation of ERBB signaling pathway |
| vesicle budding from membrane |
| gland morphogenesis |
| response to cAMP |
| regulation of osteoblast differentiation |
| developmental growth involved in morphogenesis |
| response to hydrogen peroxide |
| mammary gland development |
| branching morphogenesis of an epithelial tube |
| response to organophosphorus |
| response to estradiol |
| response to glucocorticoid |
| response to purine-containing compound |
| morphogenesis of a branching epithelium |
| response to corticosteroid |
| growth factor activity |
| positive regulation of protein kinase B signaling |
| morphogenesis of a branching structure |
| cytokine activity |
| establishment of vesicle localization |
| vesicle localization |
| positive regulation of epithelial cell proliferation |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of ossification |
| response to reactive oxygen species |
| gliogenesis |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| regulation of protein kinase B signaling |
| regulation of peptidyl-tyrosine phosphorylation |
| vesicle organization |
| response to antibiotic |
| epithelial tube morphogenesis |
| response to steroid hormone |
| regulation of epithelial cell proliferation |
| establishment of organelle localization |
| MAPK cascade |
| Golgi vesicle transport |
| response to oxidative stress |
| developmental growth |
| response to peptide hormone |
| growth |
| signal transduction by protein phosphorylation |
| gland development |
| morphogenesis of an epithelium |
| response to peptide |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to inorganic substance |
| cell population proliferation |
| tissue morphogenesis |
| organelle localization |
| cell surface |
| Golgi membrane |
| tube morphogenesis |
| neuron projection development |
| developmental process involved in reproduction |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| neuron development |
| tube development |
| response to lipid |
| membrane organization |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| animal organ morphogenesis |
| protein phosphorylation |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| intracellular transport |
| generation of neurons |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.45 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14952
- Expression level (log2 read counts): -7.68
Expression Distribution
AREG Expression in NALM6 Cells: -7.68
