ARHGAP18

Entrez Summary: N/A
UniProt Summary: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BN82002 4μM R07 exp340	1.79
Lead acetate 2000μM R08 exp497	1.98

regulation of cell shape
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein polymerization
regulation of actin filament organization
GTPase activator activity
cadherin binding
small GTPase mediated signal transduction
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
nuclear speck
positive regulation of GTPase activity
regulation of protein complex assembly
regulation of GTPase activity
regulation of cell morphogenesis
regulation of anatomical structure size
regulation of cytoskeleton organization
positive regulation of hydrolase activity
regulation of cell motility
regulation of cellular component biogenesis
regulation of locomotion
regulation of cellular component movement
regulation of anatomical structure morphogenesis
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
intracellular signal transduction
positive regulation of molecular function
regulation of intracellular signal transduction