ARHGAP21

Entrez Summary: N/A
UniProt Summary: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

maintenance of Golgi location
establishment of Golgi localization
maintenance of organelle location
Golgi localization
organelle transport along microtubule
maintenance of location in cell
Golgi organization
cytoplasmic vesicle membrane
transport along microtubule
maintenance of location
cytoskeleton-dependent intracellular transport
microtubule-based transport
actin cytoskeleton
microtubule-based movement
GTPase activator activity
regulation of small GTPase mediated signal transduction
establishment of organelle localization
positive regulation of GTPase activity
endomembrane system organization
regulation of GTPase activity
cell junction
organelle localization
Golgi membrane
microtubule-based process
positive regulation of hydrolase activity
Golgi apparatus
regulation of hydrolase activity
positive regulation of catalytic activity
intracellular transport
movement of cell or subcellular component
positive regulation of molecular function
regulation of intracellular signal transduction
establishment of localization in cell