ARHGAP44 [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGAP44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGAP44
  * **<color #00a2e8>Official Name</color>**: Rho GTPase activating protein 44
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9912|9912]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q17R89|Q17R89]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGAP44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGAP44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617716|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. {ECO:0000269|PubMed:11431473}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
|BAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modification of dendritic spine|
|negative regulation of Rac protein signal transduction|
|regulation of endosome to plasma membrane protein transport|
|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane|
|negative regulation of filopodium assembly|
|leading edge membrane|
|modification of postsynaptic structure|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|neurotransmitter receptor transport, endosome to plasma membrane|
|endosome to plasma membrane protein transport|
|regulation of Rac protein signal transduction|
|modification of synaptic structure|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|regulation of receptor localization to synapse|
|establishment of protein localization to postsynaptic membrane|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of protein localization to synapse|
|retrograde transport, endosome to plasma membrane|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|presynaptic active zone|
|receptor localization to synapse|
|regulation of dendritic spine morphogenesis|
|regulation of filopodium assembly|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|negative regulation of Ras protein signal transduction|
|establishment of protein localization to plasma membrane|
|Rac GTPase binding|
|negative regulation of small GTPase mediated signal transduction|
|protein localization to synapse|
|regulation of dendritic spine development|
|regulation of dendrite morphogenesis|
|vesicle-mediated transport to the plasma membrane|
|regulation of protein localization to plasma membrane|
|regulation of postsynapse organization|
|phospholipid binding|
|regulation of protein localization to cell periphery|
|recycling endosome|
|dendritic spine|
|regulation of dendrite development|
|negative regulation of cell projection organization|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|endosomal transport|
|regulation of intracellular protein transport|
|regulation of Ras protein signal transduction|
|postsynaptic density|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|synapse organization|
|GTPase activator activity|
|regulation of cell morphogenesis involved in differentiation|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of intracellular transport|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|dendrite|
|protein localization to membrane|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|exocytosis|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|secretion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12937
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGAP44 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>