ARHGAP44

Gene Information

Official Symbol: ARHGAP44
Official Name: Rho GTPase activating protein 44
Aliases and Previous Symbols: N/A
Entrez ID: 9912
UniProt: Q17R89
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. {ECO:0000269|PubMed:11431473}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12937
Expression level (log2 read counts): 4.21

Expression Distribution

RhoGAP
BAR

modification of dendritic spine
negative regulation of Rac protein signal transduction
regulation of endosome to plasma membrane protein transport
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
negative regulation of filopodium assembly
leading edge membrane
modification of postsynaptic structure
neurotransmitter receptor transport, endosome to postsynaptic membrane
neurotransmitter receptor transport, endosome to plasma membrane
endosome to plasma membrane protein transport
regulation of Rac protein signal transduction
modification of synaptic structure
neurotransmitter receptor transport to postsynaptic membrane
neurotransmitter receptor transport to plasma membrane
regulation of receptor localization to synapse
establishment of protein localization to postsynaptic membrane
negative regulation of plasma membrane bounded cell projection assembly
regulation of protein localization to synapse
retrograde transport, endosome to plasma membrane
protein localization to postsynaptic membrane
neurotransmitter receptor transport
presynaptic active zone
receptor localization to synapse
regulation of dendritic spine morphogenesis
regulation of filopodium assembly
regulation of postsynaptic membrane neurotransmitter receptor levels
negative regulation of Ras protein signal transduction
establishment of protein localization to plasma membrane
Rac GTPase binding
negative regulation of small GTPase mediated signal transduction
protein localization to synapse
regulation of dendritic spine development
regulation of dendrite morphogenesis
vesicle-mediated transport to the plasma membrane
regulation of protein localization to plasma membrane
regulation of postsynapse organization
phospholipid binding
regulation of protein localization to cell periphery
recycling endosome
dendritic spine