ARHGDIB [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGDIB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGDIB
  * **<color #00a2e8>Official Name</color>**: Rho GDP dissociation inhibitor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=397|397]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52566|P52566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGDIB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGDIB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rho GDI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho GDP-dissociation inhibitor activity|
|cellular response to redox state|
|negative regulation of trophoblast cell migration|
|regulation of trophoblast cell migration|
|response to redox state|
|regulation of actin cytoskeleton reorganization|
|Rac GTPase binding|
|negative regulation of reproductive process|
|Rho protein signal transduction|
|regulation of Rho protein signal transduction|
|regulation of reproductive process|
|negative regulation of multi-organism process|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|cytoplasmic vesicle|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|GTPase activator activity|
|negative regulation of cellular component movement|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|regulation of cytoskeleton organization|
|regulation of cell adhesion|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.21|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGDIB Expression in NALM6 Cells: 8.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>