ARHGDIB

Entrez Summary: N/A
UniProt Summary: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.21
Vemurafenib 6.6μM R08 exp434	-1.85

Rho GDP-dissociation inhibitor activity
cellular response to redox state
negative regulation of trophoblast cell migration
regulation of trophoblast cell migration
response to redox state
regulation of actin cytoskeleton reorganization
Rac GTPase binding
negative regulation of reproductive process
Rho protein signal transduction
regulation of Rho protein signal transduction
regulation of reproductive process
negative regulation of multi-organism process
regulation of Ras protein signal transduction
Ras protein signal transduction
cytoplasmic vesicle
negative regulation of cell migration
negative regulation of cell adhesion
negative regulation of cell motility
GTPase activator activity
negative regulation of cellular component movement
small GTPase mediated signal transduction
negative regulation of locomotion
GTPase activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
cytoskeleton
regulation of actin filament-based process
positive regulation of GTPase activity
regulation of GTPase activity
regulation of cytoskeleton organization
regulation of cell adhesion
positive regulation of hydrolase activity
regulation of multi-organism process
regulation of cell migration
regulation of cell motility
negative regulation of developmental process
regulation of locomotion
regulation of cellular component movement
negative regulation of multicellular organismal process
regulation of hydrolase activity