ARHGEF10 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ARHGEF10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF10
  * **<color #00a2e8>Official Name</color>**: Rho guanine nucleotide exchange factor 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9639|9639]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15013|O15013]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608136|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|Schwann cell development|
|centrosome duplication|
|Schwann cell differentiation|
|mitotic spindle assembly|
|kinesin binding|
|positive regulation of stress fiber assembly|
|positive regulation of actin filament bundle assembly|
|Rho guanyl-nucleotide exchange factor activity|
|peripheral nervous system development|
|mitotic spindle organization|
|regulation of stress fiber assembly|
|centrosome cycle|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|microtubule organizing center organization|
|activation of GTPase activity|
|spindle assembly|
|guanyl-nucleotide exchange factor activity|
|microtubule cytoskeleton organization involved in mitosis|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|regulation of Rho protein signal transduction|
|mitotic nuclear division|
|spindle organization|
|glial cell differentiation|
|positive regulation of supramolecular fiber organization|
|gliogenesis|
|positive regulation of cytoskeleton organization|
|regulation of Ras protein signal transduction|
|regulation of actin filament organization|
|nuclear division|
|organelle fission|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|centrosome|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|actin filament-based process|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|positive regulation of hydrolase activity|
|regulation of cellular component biogenesis|
|cell cycle process|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|neurogenesis|
|cell development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.29|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.02|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.95|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.91|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.8|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.78|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.71|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.82|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.03|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14028
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF10 Expression in NALM6 Cells: 3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>