ARHGEF10

Entrez Summary: This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
UniProt Summary: May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.29
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.02
5-Fluorouracil 2μM R00 exp1	-1.95
Rotenone 20μM R00 exp34	-1.91
Pimelic-diphenylamide-106 5μM R00 exp28	-1.88
Rapamycin 10μM R00 exp30	-1.8
CCCP 0.1μM R00 exp10	-1.78
Heregulin-B 44ng/ml R08 exp486	-1.71
BS-181 20μM R08 exp461	1.76
Etoposide 0.3μM R05 exp199	1.82
Bleomycin 5μM R08 exp459	2.03
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peripheral nervous system axon ensheathment
myelination in peripheral nervous system
Schwann cell development
centrosome duplication
Schwann cell differentiation
mitotic spindle assembly
kinesin binding
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
Rho guanyl-nucleotide exchange factor activity
peripheral nervous system development
mitotic spindle organization
regulation of stress fiber assembly
centrosome cycle
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
microtubule organizing center organization
activation of GTPase activity
spindle assembly
guanyl-nucleotide exchange factor activity
microtubule cytoskeleton organization involved in mitosis
myelination
glial cell development
ensheathment of neurons
axon ensheathment
regulation of Rho protein signal transduction
mitotic nuclear division
spindle organization
glial cell differentiation
positive regulation of supramolecular fiber organization
gliogenesis
positive regulation of cytoskeleton organization
regulation of Ras protein signal transduction
regulation of actin filament organization
nuclear division
organelle fission
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
regulation of actin filament-based process